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27474918 | Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. | 2016 Nov 10 |
2 |
| 2 |
25469771 | Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma. | 2015 Jan 8 |
1 |
| 3 |
24597676 | Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl. | 2014 Apr 14 |
1 |
| 4 |
24850316 | CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. | 2014 |
1 |
| 5 |
27485688 | Theoretical Studies on Pyrazolo[3,4-d]pyrimidine Derivatives as Potent Dual c-Src/Abl Inhibitors Using 3D-QSAR and Docking Approaches. | 2014 Mar |
2 |
| 6 |
23813855 | Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. | 2013 Aug |
1 |
| 7 |
21443205 | Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. | 2011 Apr 28 |
2 |
| 8 |
20970221 | 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. | 2010 Dec |
2 |
| 9 |
19326384 | 3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. | 2009 Jun |
1 |
| 10 |
18257513 | Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. | 2008 Mar 13 |
1 |
| 11 |
17295370 | Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells. | 2007 Mar |
4 |