Title : 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

Pub. Date : 2010 Dec

PMID : 20970221






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1 2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. pyrazolo(3,4-d)pyrimidine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 The main aim of this study was to enhance the solubility of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low solubility in aqueous media. pyrazolo(3,4-d)pyrimidine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens