| 1 |
35103870 | Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier. | 2022 Mar |
1 |
| 2 |
33028660 | Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM. | 2021 Jan |
1 |
| 3 |
33436043 | The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma. | 2021 Jan 12 |
1 |
| 4 |
34042151 | A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfate. | 2021 |
2 |
| 5 |
34815940 | Perturbed body fluid distribution and osmoregulation in response to high salt intake in patients with hereditary multiple exostoses. | 2021 Dec |
1 |
| 6 |
34956317 | Hereditary Multiple Exostoses-A Review of the Molecular Background, Diagnostics, and Potential Therapeutic Strategies. | 2021 |
1 |
| 7 |
33414810 | EXT1 and EXT2 Variants in 22 Chinese Families With Multiple Osteochondromas: Seven New Variants and Potentiation of Preimplantation Genetic Testing and Prenatal Diagnosis. | 2020 |
1 |
| 8 |
30806661 | Mutational spectrum and clinical signatures in 114 families with hereditary multiple osteochondromas: insights into molecular properties of selected exostosin variants. | 2019 Jul 1 |
1 |
| 9 |
30996093 | A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection. | 2019 Jul 1 |
1 |
| 10 |
31211456 | Insights into the molecular regulatory network of pathomechanisms in osteochondroma. | 2019 Oct |
1 |
| 11 |
31465316 | EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia. | 2019 Aug 29 |
1 |
| 12 |
29120519 | Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses. | 2018 Apr |
1 |
| 13 |
29346724 | Structural and Biophysical Characterization of Human EXTL3: Domain Organization, Glycosylation, and Solution Structure. | 2018 Feb 20 |
2 |
| 14 |
29541207 | Novel exostosin-2 mutation identified in a Chinese family with hereditary multiple osteochondroma. | 2018 Apr |
2 |
| 15 |
29545125 | Signaling systems affecting the severity of multiple osteochondromas. | 2018 Jun |
2 |
| 16 |
30054430 | The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines. | 2018 Aug 31 |
3 |
| 17 |
27744520 | MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis. | 2017 Jun |
1 |
| 18 |
28445472 | Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice. | 2017 Apr |
2 |
| 19 |
28448806 | Exostosin 1 is expressed in human odontoblasts. | 2017 Aug |
1 |
| 20 |
28466453 | Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments. | 2017 Jun |
2 |
| 21 |
28690282 | Targeted Next-Generation Sequencing Newly Identifies Mutations in Exostosin-1 and Exostosin-2 Genes of Patients with Multiple Osteochondromas. | 2017 Jul |
4 |
| 22 |
28859094 | Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. | 2017 Aug |
2 |
| 23 |
29104277 | Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation. | 2017 Nov 1 |
1 |
| 24 |
27650265 | Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2. | 2016 Sep 21 |
1 |
| 25 |
27748933 | Novel mutation of EXT2 identified in a large family with multiple osteochondromas. | 2016 Nov |
1 |
| 26 |
25829497 | Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains. | 2015 May 22 |
4 |
| 27 |
25863260 | Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses. | 2015 Jun |
2 |
| 28 |
24297320 | Novel EXT1 mutation identified in a pedigree with hereditary multiple exostoses. | 2014 Feb |
1 |
| 29 |
24409815 | Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. | 2014 Apr |
2 |
| 30 |
25230886 | A broad spectrum of genomic changes in latinamerican patients with EXT1/EXT2-CDG. | 2014 Sep 18 |
1 |
| 31 |
25468659 | Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. | 2014 Dec 2 |
3 |
| 32 |
23514715 | Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application. | 2013 Jul |
2 |
| 33 |
21956842 | Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter. | 2012 Jan |
1 |
| 34 |
22037484 | Identification and functional characterization of the human EXT1 promoter region. | 2012 Jan 15 |
1 |
| 35 |
22848466 | Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. | 2012 |
2 |
| 36 |
21586278 | Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. | 2011 Jul 15 |
1 |
| 37 |
22040554 | Mutation analysis and prenatal diagnosis of EXT1 gene mutations in Chinese patients with multiple osteochondromas. | 2011 Oct |
1 |
| 38 |
19965677 | Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma. | 2010 Jan 21 |
1 |
| 39 |
20377530 | Biosynthesis of heparan sulfate in EXT1-deficient cells. | 2010 May 27 |
9 |
| 40 |
20387539 | [Exploration of the molecular mechanism of ocular development and the creation of animal models for ocular diseases]. | 2010 Mar |
2 |
| 41 |
20807644 | Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies. | 2010 |
1 |
| 42 |
20813973 | No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas. | 2010 Oct |
2 |
| 43 |
20872591 | A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas. | 2010 Nov |
2 |
| 44 |
19839753 | Identification of four novel EXT1 and EXT2 mutations in five Chinese pedigrees with hereditary multiple exostoses. | 2009 Dec |
2 |
| 45 |
18337501 | Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. | 2008 Mar 25 |
3 |
| 46 |
18626493 | Glomerular filtration: the charge debate charges ahead. | 2008 Aug |
1 |
| 47 |
17237233 | Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. | 2007 Mar 16 |
3 |
| 48 |
17442818 | Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. | 2007 Apr 18 |
1 |
| 49 |
17761672 | Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation. | 2007 Nov 9 |
5 |
| 50 |
16622899 | EXT-related pathways are not involved in the pathogenesis of dysplasia epiphysealis hemimelica and metachondromatosis. | 2006 Jul |
1 |