| 1 |
33536335 | SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors. | 2021 Feb 9 |
1 |
| 2 |
32901871 | Checkpoint kinase‑1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair. | 2020 Nov |
3 |
| 3 |
30478995 | CtIP promotes G2/M arrest in etoposide-treated HCT116 cells in a p53-independent manner. | 2019 Jul |
1 |
| 4 |
30516086 | Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks. | 2018 |
1 |
| 5 |
28766886 | Small cell lung carcinoma cell line screen of etoposide/carboplatin plus a third agent. | 2017 Aug |
1 |
| 6 |
28928376 | Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. | 2017 Sep 19 |
3 |
| 7 |
27664008 | Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway. | 2016 Nov 15 |
1 |
| 8 |
25653093 | Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. | 2015 May |
1 |
| 9 |
26421495 | Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells. | 2015 Nov |
1 |
| 10 |
23748345 | Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia. | 2014 Feb |
1 |
| 11 |
24915421 | A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I. | 2014 Aug 1 |
1 |
| 12 |
24260231 | Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis. | 2013 |
2 |
| 13 |
18495871 | An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation. | 2008 Aug |
1 |
| 14 |
18698031 | Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil. | 2008 Aug 15 |
1 |
| 15 |
17268080 | Checkpoint kinase 1 is cleaved in a caspase-dependent pathway during genotoxic stress-induced apoptosis. | 2007 Feb |
2 |
| 16 |
16452227 | The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. | 2006 Feb 1 |
1 |
| 17 |
15674326 | Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. | 2005 Mar 17 |
6 |
| 18 |
15705874 | Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. | 2005 Feb 1 |
1 |
| 19 |
16123041 | Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. | 2005 Oct 21 |
2 |
| 20 |
11841447 | p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2M checkpoint in K562 cells, resulting in increased apoptosis. | 2002 Feb |
3 |