Title : A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

Pub. Date : 2014 Aug 1

PMID : 24915421






1 Functional Relationships(s)
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Protein Name
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1 WJ35435 was less effective than camptothecin and etoposide in inducing the phosphorylation and activation of Chk1, Chk2 and RPA32 which were crucial coordinators in DNA repair pathway, indicating a low DNA repair activity to WJ35435 action. Etoposide checkpoint kinase 1 Homo sapiens