Bilirubin

ATP binding cassette subfamily C member 2 ; Homo sapiens







52 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35281975 The Effects of Clofibrate on Neonatal Jaundice: A Systematic Review. 2022 1
2 35444014 FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression. 2022 Apr 20 2
3 35477852 In silico screening and analysis of single-nucleotide polymorphic variants of the ABCC2 gene affecting Dubin-Johnson syndrome. 2022 Apr 25 5
4 33534365 Dubin-Johnson Syndrome as Differential Diagnosis for Neonatal Cholestasis. 2021 May 1 2
5 34272713 Case Study 6: Deconvoluting Hyperbilirubinemia-Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2, or OATP1B1 in Drug Development. 2021 1
6 34604277 Clinical Risk Factors of Licorice-Induced Pseudoaldosteronism Based on Glycyrrhizin-Metabolite Concentrations: A Narrative Review. 2021 1
7 31888882 Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers. 2020 Mar 1
8 32796590 Prediction of Drug-Induced Hyperbilirubinemia by In Vitro Testing. 2020 Aug 11 2
9 27676153 Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis. 2016 Oct 17 1
10 25315738 Gene replacement therapy for genetic hepatocellular jaundice. 2015 Jun 2
11 26212029 Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. 2015 Dec 2
12 26292095 Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells. 2015 2
13 24459177 The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia. 2014 Apr 4
14 24523126 Case study 5. Deconvoluting hyperbilirubinemia: differentiating between hepatotoxicity and reversible inhibition of UGT1A1, MRP2, or OATP1B1 in drug development. 2014 1
15 24732756 Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort. 2014 1
16 25196354 Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury. 2014 2
17 25204339 Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients. 2014 Nov 1
18 25336012 Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene. 2014 Oct 2
19 29764065 Toxicogenetics of lopinavir/ritonavir in HIV-infected European patients. 2014 May 1
20 23695864 Hepatocellular organic anion-transporting polypeptides (OATPs) and multidrug resistance-associated protein 2 (MRP2) are inhibited by silibinin. 2013 Aug 1
21 24138031 Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs. 2013 Mar 3
22 22245901 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. 2012 May 3
23 22917771 Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line. 2012 Nov 1
24 23065530 Novel mutations in the Dubin-Johnson syndrome gene ABCC2/MRP2 and associated biochemical changes. 2012 Nov 2
25 21813008 Hepatic expression of multidrug resistance protein 2 in biliary atresia. 2011 Aug 3 5
26 19566819 Multidrug resistance-associated proteins and implications in drug development. 2010 Jan 1
27 20082599 ABCC2/Abcc2: a multispecific transporter with dominant excretory functions. 2010 Aug 2
28 19881259 Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome. 2009 1
29 16847695 The apical conjugate efflux pump ABCC2 (MRP2). 2007 Feb 2
30 17517076 Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis. 2007 Aug 1
31 16918320 Multidrug transporters as drug targets. 2006 Aug 1
32 16952291 Identification of a novel 974C-->G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids. 2006 Oct 2
33 15795103 Physiological, pharmacological and clinical features of the multidrug resistance protein 2. 2005 Apr 1
34 15846474 Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. 2005 Apr 1
35 15965653 Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer. 2005 Sep 2
36 16012956 Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. 2005 Jul 2
37 16080518 Involvement of ABC transporters in chemosensitivity of human renal cell carcinoma, and regulation of MRP2 expression by conjugated bilirubin. 2005 Jul-Aug 4
38 16211250 Transfecting the multidrug resistance protein 2 gene improves transcellular organic anion transport. 2005 Nov 1
39 16344598 Carbon monoxide as a guardian against hepatobiliary dysfunction. 2005 Nov 1
40 15519273 Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects. 2004 Oct 1
41 12388433 Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate. 2003 Jan 1
42 12524417 Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2). 2003 Feb 1
43 14692715 The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy. 2003 Dec 1
44 14705859 Pathophysiological factors affecting CAR gene expression. 2003 Nov 1
45 11897625 Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. 2002 Apr 1
46 12084558 Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis. 2002 May 3
47 12206135 The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. 2002 2
48 10944550 A family of drug transporters: the multidrug resistance-associated proteins. 2000 Aug 16 2
49 11023036 Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. 2000 4
50 11076395 Hepatic secretion of conjugated drugs and endogenous substances. 2000 1