Serine

signal transducer and activator of transcription 1 ; Homo sapiens







147 Article(s)
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1 34303919 Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNK. 2021 Sep 1
2 34626802 IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration. 2021 Dec 1
3 30630717 Shape-based virtual screen for the discovery of novel CDK8 inhibitor chemotypes. 2019 Feb 15 1
4 30776726 Cytokines use different intracellular mechanisms to upregulate the membrane expression of CX3CR1 in human monocytes. 2019 Apr 1
5 30920934 S27 of IFNα1 Contributes to Its Low Affinity for IFNAR2 and Weak Antiviral Activity. 2019 May 1
6 31202985 Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. 2019 Sep 1 1
7 31228268 Phosphorylation of STAT1 serine 727 enhances platinum resistance in uterine serous carcinoma. 2019 Sep 15 3
8 29394132 Decrease in invasion of HTR-8/SVneo trophoblastic cells by interferon gamma involves cross-communication of STAT1 and BATF2 that regulates the expression of JUN. 2018 1
9 29796172 Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies. 2018 May 1 1
10 29859868 Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. 2018 Sep 1
11 30007645 Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-δ signaling pathways. 2018 Oct 1 1
12 28186502 STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1. 2017 Apr 3
13 28422713 SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. 2017 May 16 1
14 28542650 Interdependence of JAK-STAT and MAPK signaling pathways during EGF-mediated HTR-8/SVneo cell invasion. 2017 6
15 28550731 Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages. 2017 Aug 1
16 28560754 Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts. 2017 Nov 1
17 29239838 Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. 2017 Dec 1
18 26141950 STAT1 Activation Is Enhanced by Cisplatin and Variably Affected by EGFR Inhibition in HNSCC Cells. 2015 Sep 1
19 24280128 NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription. 2014 Jan 15 1
20 24391115 The induction of lipocalin-2 protein expression in vivo and in vitro. 2014 Feb 28 2
21 24449862 Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1. 2014 Feb 4 1
22 24825907 Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins. 2014 Jul 11 1
23 24838635 Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma. 2014 Jul 2
24 25340519 Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells. 2014 2
25 22996189 Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ. 2013 Feb 1
26 23013371 STAT1 expression and activation is increased in lesional psoriatic skin. 2013 Feb 2
27 23349666 Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells. 2013 7
28 23562842 A chimeric cyclic interferon-α2b peptide induces apoptosis by sequential activation of phosphatidylinositol 3-kinase, protein kinase Cδ and p38 MAP kinase. 2013 Jun 10 4
29 23597922 STAT1 requirement for PKR-induced cell cycle arrest in vascular smooth muscle cells in response to heparin. 2013 Jul 15 2
30 23637938 Induction of STAT1 phosphorylation at serine 727 and expression of proinflammatory cytokines by porcine reproductive and respiratory syndrome virus. 2013 2
31 24014650 Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism. 2013 Oct 2
32 24069555 CDK8 as the STAT1 serine 727 kinase? 2013 Jul 1 2
33 22757586 Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells. 2012 Jun 7
34 23185240 Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. 2012 2
35 21135090 Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. 2011 Feb 25 1
36 21303487 Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells. 2011 Feb 6
37 22065572 Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. 2011 Dec 30 5
38 19879327 Phosphorylation-acetylation switch in the regulation of STAT1 signaling. 2010 Feb 5 1
39 19928918 Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells. 2010 Jan 27 1
40 20525893 Mechanisms of IL-12 synthesis by human dendritic cells treated with the chemical sensitizer NiSO4. 2010 Jul 1 1
41 20675591 ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. 2010 Sep 1 1
42 21084836 STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest. 2010 Dec 1 2
43 19009233 The fungal secondary metabolite trichodimerol inhibits TGF-β dependent cellular effects and tube formation of MDA-MB-231 cells. 2009 Dec 1
44 19231233 Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma. 2009 Apr 2
45 19349465 Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. 2009 Apr 13 1
46 19396596 Bortezomib pre-treatment prolongs interferon-alpha-induced STAT1 phosphorylation in melanoma cells. 2009 Dec 2
47 19404962 Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis. 2009 May 1
48 19502801 Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. 2009 Jul 1 1
49 19801665 Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. 2009 Nov 27 2
50 19846878 Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. 2009 Nov 15 3