| 1 |
35562376 | Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. | 2022 May 13 |
2 |
| 2 |
32703610 | PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease. | 2021 Apr |
2 |
| 3 |
33318871 | Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling. | 2021 Jan |
3 |
| 4 |
34649350 | Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes. | 2021 Nov |
7 |
| 5 |
32697599 | Regulation of Lin28a-miRNA let-7b-5p pathway in skeletal muscle cells by peroxisome proliferator-activated receptor delta. | 2020 Sep 1 |
1 |
| 6 |
33308300 | Mitochondrial dysfunction and consequences in calpain-3-deficient muscle. | 2020 Dec 11 |
1 |
| 7 |
30391747 | PPARδ agonist enhances colitis-associated colorectal cancer. | 2019 Jan 5 |
2 |
| 8 |
30605833 | Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents. | 2019 Feb 15 |
1 |
| 9 |
30679176 | Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. | 2019 Mar 1 |
1 |
| 10 |
30987865 | Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. | 2019 May - Jun |
1 |
| 11 |
31144304 | PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. | 2019 Aug |
1 |
| 12 |
31153636 | Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance. | 2019 Jul 23 |
1 |
| 13 |
29233935 | Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling. | 2018 Mar |
1 |
| 14 |
29388693 | Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. | 2018 Jul |
6 |
| 15 |
30204243 | Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer. | 2018 Dec 1 |
1 |
| 16 |
26661245 | Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels. | 2017 Jan |
1 |
| 17 |
28404991 | Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. | 2017 Apr 12 |
2 |
| 18 |
25331977 | Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model. | 2015 Feb |
2 |
| 19 |
25713305 | Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction. | 2015 May 1 |
1 |
| 20 |
25728706 | PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation. | 2015 May |
1 |
| 21 |
25943561 | A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. | 2015 May 6 |
2 |
| 22 |
26111938 | Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice. | 2015 Sep |
1 |
| 23 |
26604919 | PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice. | 2015 |
2 |
| 24 |
24158519 | Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice. | 2014 Jan |
2 |
| 25 |
24482374 | Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. | 2014 Apr |
1 |
| 26 |
24698256 | PPARδ reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice by regulating extracellular matrix homeostasis and inflammatory responses. | 2014 Jun 1 |
1 |
| 27 |
24864274 | PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. | 2014 Jul |
1 |
| 28 |
24920036 | Activation of peroxisome proliferator activator receptor delta in mouse impacts lipid composition and placental development at early stage of gestation. | 2014 Sep |
2 |
| 29 |
25063273 | PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. | 2014 Oct |
1 |
| 30 |
21920965 | Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks. | 2013 Jun |
1 |
| 31 |
23811944 | PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. | 2013 Jul 15 |
1 |
| 32 |
22179221 | The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. | 2012 Mar |
1 |
| 33 |
22473775 | Activation of peroxisome proliferator-activated receptor-δ attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. | 2012 Aug |
2 |
| 34 |
22886847 | Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. | 2012 Dec 1 |
1 |
| 35 |
22933110 | PPARδ activation protects endothelial function in diabetic mice. | 2012 Dec |
2 |
| 36 |
22982594 | PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice. | 2012 Nov 5 |
3 |
| 37 |
23046570 | GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. | 2012 Oct 10 |
2 |
| 38 |
21297860 | PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis. | 2011 Jan 13 |
2 |
| 39 |
21363937 | The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation. | 2011 May |
1 |
| 40 |
21511721 | Activation of peroxisome proliferators-activated receptor δ (PPARδ) promotes blastocyst hatching in mice. | 2011 Oct |
1 |
| 41 |
21617181 | Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. | 2011 Jul |
1 |
| 42 |
21966476 | GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. | 2011 |
2 |
| 43 |
22466297 | GW501516 acts as an efficient PPARα activator in the mouse liver. | 2011 Aug |
1 |
| 44 |
19538467 | PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. | 2010 Jun |
1 |
| 45 |
19903700 | PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. | 2010 Mar 1 |
1 |
| 46 |
20185762 | Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. | 2010 Apr |
3 |
| 47 |
20406305 | Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis. | 2010 Aug |
1 |
| 48 |
21318167 | Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation. | 2010 |
1 |
| 49 |
19236478 | Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. | 2009 Jul |
1 |
| 50 |
19266055 | The PPARδ ligand GW501516 reduces growth but not apoptosis in mouse inner medullary collecting duct cells. | 2009 |
1 |