GW 501516

peroxisome proliferator activator receptor delta ; Mus musculus







63 Article(s)
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1 35562376 Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. 2022 May 13 2
2 32703610 PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease. 2021 Apr 2
3 33318871 Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling. 2021 Jan 3
4 34649350 Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes. 2021 Nov 7
5 32697599 Regulation of Lin28a-miRNA let-7b-5p pathway in skeletal muscle cells by peroxisome proliferator-activated receptor delta. 2020 Sep 1 1
6 33308300 Mitochondrial dysfunction and consequences in calpain-3-deficient muscle. 2020 Dec 11 1
7 30391747 PPARδ agonist enhances colitis-associated colorectal cancer. 2019 Jan 5 2
8 30605833 Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents. 2019 Feb 15 1
9 30679176 Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. 2019 Mar 1 1
10 30987865 Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. 2019 May - Jun 1
11 31144304 PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. 2019 Aug 1
12 31153636 Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance. 2019 Jul 23 1
13 29233935 Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling. 2018 Mar 1
14 29388693 Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. 2018 Jul 6
15 30204243 Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer. 2018 Dec 1 1
16 26661245 Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels. 2017 Jan 1
17 28404991 Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. 2017 Apr 12 2
18 25331977 Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model. 2015 Feb 2
19 25713305 Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction. 2015 May 1 1
20 25728706 PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation. 2015 May 1
21 25943561 A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. 2015 May 6 2
22 26111938 Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice. 2015 Sep 1
23 26604919 PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice. 2015 2
24 24158519 Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice. 2014 Jan 2
25 24482374 Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. 2014 Apr 1
26 24698256 PPARδ reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice by regulating extracellular matrix homeostasis and inflammatory responses. 2014 Jun 1 1
27 24864274 PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. 2014 Jul 1
28 24920036 Activation of peroxisome proliferator activator receptor delta in mouse impacts lipid composition and placental development at early stage of gestation. 2014 Sep 2
29 25063273 PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. 2014 Oct 1
30 21920965 Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks. 2013 Jun 1
31 23811944 PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. 2013 Jul 15 1
32 22179221 The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. 2012 Mar 1
33 22473775 Activation of peroxisome proliferator-activated receptor-δ attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. 2012 Aug 2
34 22886847 Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. 2012 Dec 1 1
35 22933110 PPARδ activation protects endothelial function in diabetic mice. 2012 Dec 2
36 22982594 PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice. 2012 Nov 5 3
37 23046570 GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. 2012 Oct 10 2
38 21297860 PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis. 2011 Jan 13 2
39 21363937 The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation. 2011 May 1
40 21511721 Activation of peroxisome proliferators-activated receptor δ (PPARδ) promotes blastocyst hatching in mice. 2011 Oct 1
41 21617181 Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. 2011 Jul 1
42 21966476 GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. 2011 2
43 22466297 GW501516 acts as an efficient PPARα activator in the mouse liver. 2011 Aug 1
44 19538467 PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. 2010 Jun 1
45 19903700 PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. 2010 Mar 1 1
46 20185762 Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. 2010 Apr 3
47 20406305 Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis. 2010 Aug 1
48 21318167 Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation. 2010 1
49 19236478 Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. 2009 Jul 1
50 19266055 The PPARδ ligand GW501516 reduces growth but not apoptosis in mouse inner medullary collecting duct cells. 2009 1