| 1 |
34875337 | Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line. | 2022 Feb 15 |
1 |
| 2 |
34393818 | Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors - Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP. | 2021 |
1 |
| 3 |
31248114 | Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes. | 2019 Jun 19 |
2 |
| 4 |
29416006 | PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling. | 2018 Feb 7 |
2 |
| 5 |
29462984 | Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets. | 2018 Feb 19 |
2 |
| 6 |
27662514 | Role of Cyclic Nucleotide Phosphodiesterases During Meiotic Resumption From Diplotene Arrest in Mammalian Oocytes. | 2017 Mar |
2 |
| 7 |
27732797 | Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases. | 2017 Jan 6 |
1 |
| 8 |
28506928 | Distinct phosphodiesterase 5A-containing compartments allow selective regulation of cGMP-dependent signalling in human arterial smooth muscle cells. | 2017 Aug |
2 |
| 9 |
26773602 | Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network. | 2016 Feb |
1 |
| 10 |
29264117 | Effect of phosphodiesterase inhibitors in the bladder. | 2015 Jan |
1 |
| 11 |
23709025 | Enzyme assays for cGMP hydrolyzing phosphodiesterases. | 2013 |
1 |
| 12 |
23986226 | Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate release from human erythrocytes. | 2013 Sep |
2 |
| 13 |
22080917 | Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter. | 2012 Mar |
1 |
| 14 |
22261303 | Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: comparison with rat and guinea pig. | 2012 Feb 27 |
1 |
| 15 |
22918733 | Targeting phosphodiesterases in anti-platelet therapy. | 2012 |
2 |
| 16 |
21649691 | Anti-platelet therapy: phosphodiesterase inhibitors. | 2011 Oct |
1 |
| 17 |
20491634 | PDE5 inhibitors and their applications. | 2010 |
1 |
| 18 |
19060915 | Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts. | 2009 Jan |
1 |
| 19 |
19267844 | Phosphodiesterase type 5 regulation in the penile corpora cavernosa. | 2009 Mar |
2 |
| 20 |
19352616 | [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study]. | 2009 Jul |
1 |
| 21 |
18234184 | PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. | 2008 Mar 17 |
2 |
| 22 |
17498099 | Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora. | 2007 May |
1 |
| 23 |
17606845 | Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. | 2007 Jul 17 |
1 |
| 24 |
16407275 | Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity. | 2006 Mar 3 |
2 |
| 25 |
17017938 | Expression, distribution and regulation of phosphodiesterase 5. | 2006 |
5 |
| 26 |
15769620 | Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system. | 2005 May 1 |
1 |
| 27 |
15907910 | Pulmonary hypertension: inhaled nitric oxide, sildenafil and natriuretic peptides. | 2005 Jun |
1 |
| 28 |
16325746 | Regulation of phosphodiesterase 5 expression and activity in human pregnant and non-pregnant myometrial cells by human chorionic gonadotropin. | 2005 Dec |
1 |
| 29 |
15224132 | Implications of PDE4 structure on inhibitor selectivity across PDE families. | 2004 Jun |
1 |
| 30 |
15271668 | cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo. | 2004 Dec |
2 |
| 31 |
12359732 | Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity. | 2002 Dec 6 |
1 |
| 32 |
11162575 | Identification and regulation of human PDE5A gene promoter. | 2001 Jan 26 |
1 |
| 33 |
11358813 | Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. | 2001 May 15 |
1 |
| 34 |
10411650 | Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases. | 1999 Jun |
1 |
| 35 |
10506154 | Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). | 1999 Oct 8 |
4 |
| 36 |
9115850 | Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. | 1996 Dec |
1 |