Serine

insulin receptor substrate 1 ; Homo sapiens







331 Article(s)
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301 11287630 A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. 2001 Apr 10 3
302 11313980 Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells. 2001 Jan 25 4
303 11498541 Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. 2001 Oct 12 1
304 11682617 Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. 2001 Nov 2
305 10764799 Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells. 2000 Jul 7 2
306 10781824 Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner. 2000 Apr 21 2
307 10830273 Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. 2000 Jun 4
308 10847581 A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. 2000 Jun 3
309 10852715 A single substitution of the insulin receptor kinase inhibits serine autophosphorylation in vitro: evidence for an interaction between the C-terminus and the activation loop. 2000 Jun 20 1
310 10866039 Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. 2000 Jun 1
311 11043572 Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. 2000 Oct 5
312 10092613 Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway. 1999 Apr 2 5
313 10318852 Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. 1999 May 14 1
314 10488146 JAK1-dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation. 1999 Sep 24 14
315 10497255 Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. 1999 Oct 1 5
316 9422753 14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes. 1998 Jan 9 2
317 9565570 Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2. 1998 May 8 1
318 9686926 Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). 1998 Jul 4
319 9761740 Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase. 1998 Oct 15 3
320 9832428 Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. 1998 Dec 9
321 9849961 Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation. 1998 Dec 3
322 9036989 Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha. 1997 Mar 1 2
323 9312143 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. 1997 Oct 3 6
324 9335553 Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. 1997 Oct 21 2
325 9395471 Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. 1997 Dec 12 3
326 8626671 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. 1996 May 10 8
327 8660383 Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells. 1996 Jun 5 2
328 7818531 The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes. 1995 Jan 5 4
329 7998930 Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. 1994 Nov 15 4
330 8119950 Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. 1994 Feb 25 5
331 8513971 Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. 1993 Jul 1