talazoparib

BRCA1 DNA repair associated ; Homo sapiens







47 Article(s)
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1 34958867 Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells. 2022 Mar 2
2 35091441 Determinants of Response to Talazoparib in Patients with HER2-Negative, Germline BRCA1/2-Mutated Breast Cancer. 2022 Apr 1 1
3 35163586 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC. 2022 Jan 31 1
4 35607887 Talazoparib in BRCA-mutated advanced breast cancer: isĀ earlier better? 2022 Jun 1
5 33710534 An Overview of PARP Inhibitors for the Treatment of Breast Cancer. 2021 May 1
6 34231369 Indirect treatment comparison of olaparib and talazoparib in germline BRCA-mutated HER2-negative metastatic breast cancer. 2021 Sep 2
7 34309473 Development of the PARP inhibitor talazoparib for the treatment of advanced BRCA1 and BRCA2 mutated breast cancer. 2021 Oct 1
8 31823331 Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations. 2020 Feb 1
9 32158196 Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC-MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies. 2020 2
10 32162822 Talazoparib in Patients with a Germline BRCA-Mutated Advanced Breast Cancer: Detailed Safety Analyses from the Phase III EMBRACA Trial. 2020 Mar 3
11 32195033 Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. 2020 1
12 32215876 Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond. 2020 Jun 1
13 32243226 Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline. 2020 Jun 20 1
14 32276934 Manage wisely: poly (ADP-ribose) polymerase inhibitor (PARPi) treatment and adverse events. 2020 Jul 1
15 32337496 Outcomes in Clinically Relevant Patient Subgroups From the EMBRACA Study: Talazoparib vs Physician's Choice Standard-of-Care Chemotherapy. 2020 Feb 1
16 32468579 Talazoparib Exposure-Efficacy Analysis in Patients With Advanced Breast Cancer and Germline BRCA1/2 Mutations in the EMBRACA Trial. 2020 Oct 1
17 32468645 Exposure-Safety Analyses of Talazoparib in Patients With Advanced Breast Cancer and Germline BRCA1/2 Mutations in the EMBRACA and ABRAZO Trials. 2020 Oct 1
18 32471249 PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond? 2020 May 27 1
19 32717529 The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction. 2020 Oct 1 1
20 32816949 A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer. 2020 Oct 15 1
21 32828825 Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial. 2020 Nov 1
22 32869930 Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer. 2020 Nov 1
23 32881420 Paired tumor sequencing and germline testing in breast cancer management: An experience of a single academic center. 2020 Dec 1
24 33257598 Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis. 2020 Nov 30 3
25 33490218 Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis? 2020 Dec 1
26 30563931 A Phase II Study of Talazoparib after Platinum or Cytotoxic Nonplatinum Regimens in Patients with Advanced Breast Cancer and Germline BRCA1/2 Mutations (ABRAZO). 2019 May 1 4
27 30789866 Integrating poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of early breast cancer. 2019 May 1
28 30806045 Major clinical research advances in gynecologic cancer in 2018. 2019 Mar 1
29 30912451 Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib. 2019 May 1
30 31099663 Germline Genetic Testing for Breast Cancer Risk: The Past, Present, and Future. 2019 Jan 1
31 31303769 Evidence to date: talazoparib in the treatment of breast cancer. 2019 1
32 31347614 Talazoparib to treat BRCA-positive breast cancer. 2019 Jul 3
33 29189915 Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations. 2018 Feb 1
34 29242215 Talazoparib Bests Chemo for Breast Cancer. 2018 Feb 1
35 29660759 PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside. 2018 Jun 15 1
36 30061215 Development and Evaluation of Talazoparib Nanoemulsion for Systemic Therapy of BRCA1-mutant Cancer. 2018 Aug 1
37 30110579 Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation. 2018 Aug 23 2
38 30124753 Quality of life with talazoparib versus physician's choice of chemotherapy in patients with advanced breast cancer and germline BRCA1/2 mutation: patient-reported outcomes from the EMBRACA phase III trial. 2018 Sep 1 1
39 30146245 Talazoparib for BRCA-mutated advanced breast cancer. 2018 Oct 1
40 30181424 Resurrection of PARP Inhibitors in Breast Cancer. 2018 Sep 1
41 30255456 Synthetically Lethal BMN 673 (Talazoparib) Loaded Solid Lipid Nanoparticles for BRCA1 Mutant Triple Negative Breast Cancer. 2018 Sep 25 1
42 30359909 Quality of life with talazoparib after platinum or multiple cytotoxic non-platinum regimens in patients with advanced breast cancer and germline BRCA1/2 mutations: patient-reported outcomes from the ABRAZO phase 2 trial. 2018 Nov 1
43 30506138 Talazoparib: First Global Approval. 2018 Dec 1
44 30518089 Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. 2018 Dec 4 2
45 28242752 Phase I, Dose-Escalation, Two-Part Trial of the PARP Inhibitor Talazoparib in Patients with Advanced Germline BRCA1/2 Mutations and Selected Sporadic Cancers. 2017 Jun 2
46 29238749 A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity. 2017 3
47 27708213 Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. 2016 Nov 22 1