2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

BCL2, apoptosis regulator ; Rattus norvegicus







35 Article(s)
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1 33772736 PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells. 2022 Feb 1
2 35179214 Protective role of wogonin following traumatic brain injury by reducing oxidative stress and apoptosis via the PI3K/Nrf2/HO‑1 pathway. 2022 Apr 1
3 33188898 Protection by rhynchophylline against MPTP/MPP+-induced neurotoxicity via regulating PI3K/Akt pathway. 2021 Mar 25 1
4 33734020 Morroniside protects OLN-93 cells against H2O2-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities. 2021 Apr 1
5 34273708 10-O-(N N-Dimethylaminoethyl)-Ginkgolide B Methane-Sulfonate (XQ-1H) Ameliorates Cerebral Ischemia Via Suppressing Neuronal Apoptosis. 2021 Sep 1
6 31904495 A combination of Semen Cuscutae and Fructus Lycii improves testicular cell proliferation and inhibits their apoptosis in rats with spermatogenic dysfunction by regulating the SCF/c-kit--PI3K--Bcl-2 pathway. 2020 Apr 6 1
7 32869594 [Effect of electroacupuncture on neuronal apoptosis in rats with traumatic brain injury based on PI3K/Akt signaling pathway]. 2020 Aug 12 1
8 30374891 Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3β signaling pathway in hippocampus. 2019 Feb 1
9 30569126 Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats. 2019 Feb 1
10 31120770 Hypoxic postconditioning activates the Wnt/β-catenin pathway and protects against transient global cerebral ischemia through Dkk1 Inhibition and GSK-3β inactivation. 2019 Aug 1
11 31544532 Osteopontin promotes rat hepatocyte proliferation both in vitro and in vivo. 2019 Dec 1
12 29687856 Granulocyte colony-stimulating factor improves neurological function and angiogenesis in intracerebral hemorrhage rats. 2018 Apr 1
13 30116338 Expression of Bcl-2 and Bad in hippocampus of status epileptic rats and molecular mechanism of intervened recombinant human erythropoietin. 2018 Aug 2
14 28549860 Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway. 2017 Jul 12 1
15 28645007 Activation of the PI3K-Akt pathway promotes neuroprotection of the δ-opioid receptor agonist against cerebral ischemia-reperfusion injury in rat models. 2017 Sep 1
16 26414235 Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway. 2016 1
17 26992405 Sulfiredoxin-1 protects against simulated ischaemia/reperfusion injury in cardiomyocyte by inhibiting PI3K/AKT-regulated mitochondrial apoptotic pathways. 2016 1
18 27328502 Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells. 2016 1
19 25705234 Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells. 2015 1
20 25744447 Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke. 2015 Jun 3
21 25955216 Cadmium-induced autophagy promotes survival of rat cerebral cortical neurons by activating class III phosphoinositide 3-kinase/beclin-1/B-cell lymphoma 2 signaling pathways. 2015 Aug 1
22 26485504 Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity. 2015 Nov 15 1
23 26677708 [Effect of puerarin on PI3K/AKT pathway-mediated apoptosis of PASMCs]. 2015 Aug 2
24 24157854 Electro-acupuncture at points of Zusanli and Quchi exerts anti-apoptotic effect through the modulation of PI3K/Akt signaling pathway. 2014 Jan 13 1
25 21800153 Involvement of K(ATP)/PI (3)K/AKT/Bcl-2 pathway in hydrogen sulfide-induced neuroprotection against the toxicity of 1-methy-4-phenylpyridinium ion. 2012 Feb 1
26 23054633 Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis. 2012 Oct 1
27 23271286 Involvement of PI3K/Akt pathway in the neuroprotective effect of Sonic hedgehog on cortical neurons under oxidative stress. 2012 Dec 1
28 21590646 Alpha-lipoic acid inhibits endoplasmic reticulum stress-induced cell death through PI3K/Akt signaling pathway in FRTL5 thyroid cells. 2011 Jun 2
29 19151742 Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway. 2009 Feb 1
30 18785877 Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. 2008 Sep 1
31 17242177 Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress. 2007 Feb 1
32 17629357 Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. 2007 Nov-Dec 1
33 16018989 The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. 2005 Aug 2 1
34 11773707 Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. 2002 Feb 7
35 10753867 Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. 2000 Apr 14 1