PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16018989-10 2005 Furthermore, LY294002 significantly strengthened both peaks of JNK1/2 activation, c-Jun activation, Bcl-2 phosphorylation, and the activation of caspase-3 during reperfusion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 BCL2, apoptosis regulator Rattus norvegicus 100-105 34273708-8 2021 For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 BCL2, apoptosis regulator Rattus norvegicus 106-111 11773707-0 2002 Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 BCL2, apoptosis regulator Rattus norvegicus 55-60 11773707-0 2002 Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 BCL2, apoptosis regulator Rattus norvegicus 116-121 11773707-7 2002 Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 BCL2, apoptosis regulator Rattus norvegicus 63-68 11773707-7 2002 Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 BCL2, apoptosis regulator Rattus norvegicus 133-138 11773707-7 2002 Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 BCL2, apoptosis regulator Rattus norvegicus 133-138 11773707-9 2002 In OKA treated cells that were pre-treated with Ly294002, bcl-2 was highly co-localized with mitochondria, but in cells treated with okadaic acid alone, bcl-2 was associated with fragmented chromatin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 BCL2, apoptosis regulator Rattus norvegicus 58-63 11773707-10 2002 In this model, it appears that LY294002 may exert anti-apoptotic effects by a previously unreported treatment related increase in bcl-2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-39 BCL2, apoptosis regulator Rattus norvegicus 130-135 10753867-7 2000 Pharmacological inhibition of phosphatidylinositol (PI) 3-kinase, the upstream kinase of Akt, with LY294002 led to a 45% decrease in Bcl-2 promoter activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 BCL2, apoptosis regulator Rattus norvegicus 133-138 35179214-13 2022 In addition, LY294002 partially reversed the regulation of wogonin on NOX2, caspase-3, Bax and Bcl-2 proteins. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 BCL2, apoptosis regulator Rattus norvegicus 95-100 33772736-10 2022 Meanwhile, LY294002 pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3 mRNAs and decreased Bcl-2 mRNA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 11-19 BCL2, apoptosis regulator Rattus norvegicus 123-128 33734020-9 2021 LY294002 also inhibited the expression of SOD and Bcl-2, and increased the expression of iNOS and c-caspase-3 induced by MR treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 50-55 32869594-8 2020 Compared with the LY294002+EA group, the number of neuronal apoptosis in the left cortex was decreased in the EA group (P<0.01), and the expression of Bax, Caspase-9 and Cyt-C was decreased (P<0.01, P<0.05), and the expression of p-Akt/Akt and Bcl-2 was increased (P<0.01). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 BCL2, apoptosis regulator Rattus norvegicus 244-249 33188898-12 2021 Moreover, the Rhy-induced decreases of Bax and caspase-3 as the proapoptotic markers and the increase of Bcl-2 as the antiapoptotic marker, were blocked by LY294002 in the MPP+-treated PC12 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 156-164 BCL2, apoptosis regulator Rattus norvegicus 105-110 31120770-8 2019 Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-39 BCL2, apoptosis regulator Rattus norvegicus 203-208 31904495-16 2020 The expression of p-Akt and Bcl-2 decreased, while that of Bad and Bax increased in the LY + SCFL group compared with the SCFL group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 88-90 BCL2, apoptosis regulator Rattus norvegicus 28-33 31544532-9 2019 Furthermore, rrOPN promoted the expression of p-STAT3 and p-AKT, while OPN-Ab and PI3K/Akt inhibitor LY294002 both inhibited the expressions of p-AKT and Bcl2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 101-109 BCL2, apoptosis regulator Rattus norvegicus 154-158 30374891-15 2019 When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 BCL2, apoptosis regulator Rattus norvegicus 245-250 30569126-5 2019 LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 257-262 30116338-6 2018 The expression of Bad protein and Bad mRNA in hippocampus increased while the p-Akt, Bcl-2, Bcl-2 mRNA decreased significantly in the LY294002 treated group compared with the rHuEpo treated group (P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 134-142 BCL2, apoptosis regulator Rattus norvegicus 85-90 30116338-6 2018 The expression of Bad protein and Bad mRNA in hippocampus increased while the p-Akt, Bcl-2, Bcl-2 mRNA decreased significantly in the LY294002 treated group compared with the rHuEpo treated group (P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 134-142 BCL2, apoptosis regulator Rattus norvegicus 92-97 26992405-12 2016 Importantly, LY294002 mitigated the inhibitory effects of Srx-1 on Deltapsim loss, cytochrome c release, caspase-9/3 activity, and the expression of Bcl-2 family. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 BCL2, apoptosis regulator Rattus norvegicus 149-154 29687856-10 2018 LY294002 significantly decreased p-AKT, Bcl-2, and VEGF expressions, and alleviated the cell apoptosis protective and angiogenesis effect induced by G-CSF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 40-45 28645007-7 2017 Decreased mRNA and protein expressions of PI3K and Bcl-2, reduced protein expressions of p-Akt and p-Bad and elevated mRNA and protein expressions of Bax exhibited in the LY294002 group than the DADLE group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 171-179 BCL2, apoptosis regulator Rattus norvegicus 51-56 28549860-13 2017 Moreover, treatment with LY294002, a PI3K inhibitor, abrogated CS-TG (200mug/mL) induced down-regulation of cleaved caspase-3, Bax/Bcl-2 in the serum. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 BCL2, apoptosis regulator Rattus norvegicus 131-136 26414235-7 2016 The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 BCL2, apoptosis regulator Rattus norvegicus 142-147 27328502-5 2016 Protein expressions of Bad, Bax, and Foxo3a in GCs in APJ-siRNA group, LY294002 group, and HIMO group were apparently upregulated (p < 0.05), and the protein expression of Bcl-2 in APJ-siRNA group, LY294002 group, and HIMO group was obviously downregulated (p < 0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 201-209 BCL2, apoptosis regulator Rattus norvegicus 175-180 26677708-7 2015 Both LY294002 and Pue can inhibit hypoxia-induced Bcl-2, up-regulation of P-AKT expression and down-regulation of Bax expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5-13 BCL2, apoptosis regulator Rattus norvegicus 50-55 26485504-8 2015 LY294002 (phosphatidylinositol-3 kinase (PI3K) inhibitor) and PD98059 (extracellular signal regulates kinase-1/2 (ERK1/2) inhibitor) obviously reduced baicalin-induced MRTF-A expression and transactivity and expression of MCL-1 and BCL-2, which further abolished the anti-apoptotic effect of baicalin on neuronal apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 232-237 25955216-7 2015 LY294002, a specific inhibitor of PI3K, prevented the decline in Bcl-2 production and the increase in levels of beclin-1, class III PI3K and autophagy following Cd treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 65-70 26677708-8 2015 Compared with the hypoxia + Pue group or the hypoxia + LY294002 group, the hypoxia + Pue + LY294002 group showed more significantly changes in Bcl-2, Bax, P-AKT expressions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 91-99 BCL2, apoptosis regulator Rattus norvegicus 143-148 25744447-8 2015 Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 BCL2, apoptosis regulator Rattus norvegicus 76-81 25744447-8 2015 Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 BCL2, apoptosis regulator Rattus norvegicus 202-207 25744447-8 2015 Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 BCL2, apoptosis regulator Rattus norvegicus 202-207 21590646-8 2011 After LY294002 administration in non-TN-treated cells, cell viability was reduced, and CHOP and Bax protein levels were elevated, and Bcl-2 protein levels were reduced. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 BCL2, apoptosis regulator Rattus norvegicus 134-139 25705234-5 2015 LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 in Abeta 25-35-treated PC12 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 140-145 23271286-13 2012 LY294002 treatment could up-regulate the expression of the pro-apoptotic gene Bax by 12% and down-regulate the expression of the anti-apoptotic gene Bcl-2 by 54%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 149-154 23054633-7 2012 Moreover, LY294002 inhibited the phosphorylated-Akt expression evoked by SFN, decreased Bcl-2 expression and increased cleaved caspase-3 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 BCL2, apoptosis regulator Rattus norvegicus 88-93 21800153-3 2012 In addition, NaHS up-regulated the expression of Bcl-2 and blocked MPP(+)-induced down-regulation of Bcl-2, and this augmentation of Bcl-2 expression was prevented by both glybenclamide and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 190-198 BCL2, apoptosis regulator Rattus norvegicus 49-54 24157854-7 2014 The selective PI3K inhibitor LY294002 compromised EA-induced neuroprotective effects and reduced the elevation of p-Akt, p-Bad and Bcl-2 levels. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 BCL2, apoptosis regulator Rattus norvegicus 131-136 21590646-10 2011 LY294002 and wortmannin decreased cell viability, and increased CHOP and Bax protein levels, and decreased Bcl-2 protein levels in ALA-pretreated and TN-treated cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 107-112 18785877-9 2008 Also, treatment with LY294002 significantly inhibited expression of Bcl-2, but PD98059 showed no significant effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 BCL2, apoptosis regulator Rattus norvegicus 68-73 19151742-8 2009 RESULTS: Geniposide induced the expression of the antiapoptotic protein Bcl-2, which inhibited apoptosis in PC12 cells induced by H(2)O(2), and this effect could be inhibited by preincubation with LY294002, a selective inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 197-205 BCL2, apoptosis regulator Rattus norvegicus 72-77 17629357-6 2007 LY294002 (a PI3K inhibitor) inhibited the effect of geniposide increasing of Bcl-2 level by activation of MAPK, MEK and c-Raf phosphorylation in hydrogen peroxide treated PC12 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 BCL2, apoptosis regulator Rattus norvegicus 77-82 17242177-10 2007 Indeed, HGF increased mRNA and protein expression of bcl-2 downregulated by FFAs-treatment; moreover, pre-treatment with the specific PI3-kinase inhibitor LY294002, significantly abolished the protective effect of HGF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 155-163 BCL2, apoptosis regulator Rattus norvegicus 53-58