| 1 |
33484942 | Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors. | 2021 Mar |
1 |
| 2 |
33784602 | Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors. | 2021 Jun 5 |
1 |
| 3 |
33986726 | Recent Understanding and Future Directions of Recurrent Corticotroph Tumors. | 2021 |
1 |
| 4 |
34555628 | Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs). | 2021 Nov |
2 |
| 5 |
32433863 | Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2. | 2020 Jul 17 |
2 |
| 6 |
31038080 | Novel Pyrazolo[3,4-d]pyrimidines as Potential Cytotoxic Agents: Design, Synthesis, Molecular Docking and CDK2 Inhibition. | 2019 |
3 |
| 7 |
31452106 | Docking with SwissDock. | 2019 |
1 |
| 8 |
31462218 | Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine. | 2019 Aug 28 |
2 |
| 9 |
31513938 | Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitors. | 2019 Nov |
1 |
| 10 |
28128514 | Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles. | 2017 Apr 5 |
3 |
| 11 |
28911822 | Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors. | 2017 Dec 15 |
3 |
| 12 |
27898692 | Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells. | 2016 |
3 |
| 13 |
25870074 | Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation. | 2015 Jul |
1 |
| 14 |
25942479 | Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. | 2015 Jul |
1 |
| 15 |
26054755 | MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation. | 2015 Jun 22 |
1 |
| 16 |
26151768 | Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study. | 2015 Sep |
2 |
| 17 |
24606123 | Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. | 2014 Apr |
1 |
| 18 |
25074870 | Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1. | 2014 Oct |
1 |
| 19 |
23042366 | Osteosarcoma cells induce endothelial cell proliferation during neo-angiogenesis. | 2013 Apr |
3 |
| 20 |
23437375 | Molecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin E. | 2013 |
1 |
| 21 |
24058495 | Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design. | 2013 |
1 |
| 22 |
22829544 | Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein. | 2012 Oct |
1 |
| 23 |
21209116 | Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. | 2011 Mar |
1 |
| 24 |
21328450 | Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells. | 2011 Mar |
1 |
| 25 |
21391976 | Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9. | 2011 Jul |
1 |
| 26 |
21411497 | Nitrite-mediated modulation of HL-60 cell cycle and proliferation: involvement of cyclin-dependent kinase 2 activation. | 2011 Jun |
1 |
| 27 |
21417417 | Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. | 2011 Apr 28 |
1 |
| 28 |
21550420 | Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus. | 2011 Aug |
1 |
| 29 |
19956888 | Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells. | 2010 Jan |
2 |
| 30 |
20079829 | Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle. | 2010 Mar 15 |
1 |
| 31 |
20145171 | Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors. | 2010 Feb 15 |
1 |
| 32 |
20822897 | Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies. | 2010 Dec |
2 |
| 33 |
20850841 | Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma. | 2010 Nov |
1 |
| 34 |
19448431 | The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. | 2009 Jun 1 |
1 |
| 35 |
19497615 | Improved efficiency of canine nucleus transfer using roscovitine-treated canine fibroblasts. | 2009 Sep 1 |
1 |
| 36 |
17942543 | Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome. | 2008 Jan |
1 |
| 37 |
18202766 | Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells. | 2008 Feb |
1 |
| 38 |
18617527 | Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. | 2008 Sep 12 |
1 |
| 39 |
18761329 | Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells. | 2008 Dec 1 |
4 |
| 40 |
18761330 | Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells. | 2008 Dec 1 |
2 |
| 41 |
18784074 | Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. | 2008 Nov 7 |
2 |
| 42 |
18790752 | N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. | 2008 Sep |
2 |
| 43 |
16770643 | Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations. | 2007 Jan |
3 |
| 44 |
17125805 | Roscovitine differentially affects CaV2 and Kv channels by binding to the open state. | 2007 Mar |
1 |
| 45 |
17203463 | Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. | 2007 Mar 1 |
2 |
| 46 |
17325859 | Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas. | 2007 Jan |
2 |
| 47 |
17404016 | Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells. | 2007 Jan |
2 |
| 48 |
17713901 | Significance of water molecules in the inhibition of cylin-dependent kinase 2 and 5 complexes. | 2007 Sep-Oct |
3 |
| 49 |
16575928 | Interaction energies for the purine inhibitor roscovitine with cyclin-dependent kinase 2: correlated ab initio quantum-chemical, DFT and empirical calculations. | 2006 May 24 |
3 |
| 50 |
16733081 | Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells. | 2006 Jul 24 |
2 |