Title : Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Pub. Date : 2012 Oct

PMID : 22829544






1 Functional Relationships(s)
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1 These results indicate that roscovitine stimulated the expression of UGT1A1 by inhibiting CDK2, which phosphorylated PXR at Ser350 to suppress binding with RXR and coactivator and maintain the acetylation of PXR protein. Roscovitine cyclin dependent kinase 2 Homo sapiens