Serine

cyclin dependent kinase 5 ; Homo sapiens







110 Article(s)
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1 35190642 O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation. 2022 Apr 1
2 33098871 Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity. 2021 Jan 1
3 34814918 Three decades of Cdk5. 2021 Nov 23 1
4 32286796 Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease. 2020 May 6 4
5 32352232 Retrospective assessment of cyclin-dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer. 2020 Jun 2
6 32571373 Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury. 2020 Jun 22 2
7 33142057 A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities. 2020 Nov 12 1
8 31013770 Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. 2019 Apr 12 3
9 31163256 Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction. 2019 Sep 3
10 31272499 CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. 2019 Jul 4 1
11 31354714 Cdk5 Deletion Enhances the Anti-inflammatory Potential of GC-Mediated GR Activation During Inflammation. 2019 1
12 31371703 Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity. 2019 Aug 2 2
13 31488827 CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. 2019 Sep 5 1
14 31496920 CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC. 2019 4
15 28877958 Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. 2018 Jan 2
16 29782227 Cdk5-mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress. 2018 1
17 30199253 Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. 2018 Sep 27 1
18 30237421 Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. 2018 Sep 20 1
19 28477132 Study of ATM Phosphorylation by Cdk5 in Neuronal Cells. 2017 2
20 28526617 Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease. 2017 Jun 2
21 28956329 Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases. 2017 1
22 29056962 Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ. 2017 1
23 26088971 Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology. 2016 Jul 2
24 26601962 Neuroprotective Mechanisms Mediated by CDK5 Inhibition. 2016 2
25 27346674 Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation. 2016 Jun 27 2
26 27438154 Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas. 2016 Aug 9 3
27 25533468 Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. 2015 Feb 20 2
28 25760044 Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. 2015 2
29 25903132 Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. 2015 Jun 5 2
30 25909891 Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway. 2015 Nov 1
31 25959509 PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility. 2015 Jul 1 2
32 26002103 CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death. 2015 Aug 15 1
33 26237679 Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. 2015 4
34 26555036 Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis. 2015 Nov 10 1
35 23968571 Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5. 2014 Feb 2
36 24498195 ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. 2014 1
37 24607229 Memory enhancement by targeting Cdk5 regulation of NR2B. 2014 Mar 5 2
38 24668294 Kinome profiling of osteoblasts on hydroxyapatite opens new avenues on biomaterial cell signaling. 2014 Sep 2
39 25076872 Physiological and pathological phosphorylation of tau by Cdk5. 2014 2
40 25452387 CDK5 is a major regulator of the tumor suppressor DLC1. 2014 Dec 8 1
41 22617848 WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. 2013 Jun 1
42 23362255 Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. 2013 Mar 15 1
43 23562662 Transient expression, purification and characterisation of human full-length PPARγ2 in HEK293 cells. 2013 Jun 2
44 23762397 Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway. 2013 1
45 23979715 Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation. 2013 Sep 2 1
46 24085300 Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. 2013 Nov 8 1
47 24091658 EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. 2013 Oct 3 1
48 24121667 CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. 2013 Oct 14 1
49 24391960 Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling. 2013 1
50 21922195 The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. 2012 Mar 1