Rotenone

synuclein alpha ; Rattus norvegicus







50 Article(s)
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1 34558543 Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease. 2022 May 2
2 34656609 The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats. 2022 Jan 5 1
3 34896331 Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells. 2022 Feb 1 1
4 33220427 Isolongifolene mitigates rotenone-induced dopamine depletion and motor deficits through anti-oxidative and anti-apoptotic effects in a rat model of Parkinson's disease. 2021 Mar 1
5 33578261 Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation. 2021 May 3
6 33927622 Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease. 2021 1
7 34361780 Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways. 2021 Jul 30 1
8 32905883 α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. 2020 Oct 1
9 33081327 Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. 2020 Oct 16 1
10 31185705 Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease. 2019 Jun 10 1
11 31408200 Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. 2019 Dec 1
12 29196028 Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. 2018 Feb 10 1
13 29327204 Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects. 2018 Aug 1
14 30059366 Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways. 2018 Sep 26 1
15 27585560 Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats. 2017 Jan 1 2
16 27876560 Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study. 2017 Jan 15 2
17 28132806 Rifampicin pre-treatment inhibits the toxicity of rotenone-induced PC12 cells by enhancing sumoylation modification of α-synuclein. 2017 Mar 25 3
18 28349030 Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. 2017 Feb 2
19 28619113 Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates. 2017 Jun 15 1
20 29181664 Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone. 2017 Dec 2
21 27473339 From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. 2016 Oct 1
22 27632381 Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease. 2016 1
23 27706423 Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology. 2016 Sep 1
24 24946750 Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease. 2015 Feb 1
25 25433145 The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway. 2015 Mar 4 4
26 25446361 Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease. 2015 Jan 22 2
27 26075822 shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. 2015 Jul 1 5
28 26649942 A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. 2015 Nov 2 3
29 24833599 Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. 2014 Oct 1
30 23128054 Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells. 2013 Jan 3
31 23229893 SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases. 2013 Jan 1
32 23295396 The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats. 2013 Apr 15 2
33 23567316 Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. 2013 Jun 7 2
34 24002177 14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy. 2013 Nov 1
35 22198020 Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone. 2012 Feb 17 1
36 22490660 [Adenovirus vector mediated human 14-3-3 γ gene transfer protects dopaminergic cells against rotenone-induced injury]. 2012 Jan 3 1
37 19626387 Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein. 2010 Feb 2
38 21067569 Protein aggregation containing β-amyloid, α-synuclein and hyperphosphorylated τ in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. 2010 Nov 10 1
39 19595768 Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. 2009 Oct 1
40 19924288 Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease. 2009 Nov 18 1
41 18289173 Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. 2008 Mar 1
42 17273802 Alpha-synuclein and tyrosine hydroxylase expression in acute rotenone toxicity. 2007 Mar 1
43 17690729 alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats. 2006 Sep 6
44 15790535 Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. 2005 Mar 24 1
45 15084427 The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA. 2004 May 5 1
46 15265640 L-DOPA reverses the hypokinetic behaviour and rigidity in rotenone-treated rats. 2004 Aug 31 1
47 15280438 Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. 2004 Dec 1
48 12504863 Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. 2003 Jan 3
49 12177198 An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. 2002 Aug 15 1
50 11100151 Chronic systemic pesticide exposure reproduces features of Parkinson's disease. 2000 Dec 1