Title : Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats.

Pub. Date : 2017 Jan 1

PMID : 27585560






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1 In this context, the aim of this study was to assess the behavioural and neuropathological impact of exposing rats with a subclinical load of alpha-synuclein to subclinical doses of the organic pesticide, rotenone. Rotenone synuclein alpha Rattus norvegicus
2 These results indicate that exposing rats with a subclinical alpha-synuclein-induced pathology to the pesticide, rotenone, profoundly exacerbates their Parkinsonian neuropathology and dysfunction, and highlights the potential importance of this interaction in the etiology of, and in driving the pathogenesis of Parkinson"s disease. Rotenone synuclein alpha Rattus norvegicus