Glycine

glutamate ionotropic receptor NMDA type subunit 2A ; Homo sapiens







39 Article(s)
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1 34233182 Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKII╬▒ phosphorylation of the GluN2A subunit. 2021 Jul 6 2
2 34321660 Structural basis of ketamine action on human NMDA receptors. 2021 Aug 1
3 34504293 Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains. 2021 Sep 9 1
4 33122756 The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors. 2020 Oct 29 1
5 29644724 A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder. 2018 Jul 1
6 28228639 GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function. 2017 Jun 1
7 28468946 Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077. 2017 Jul 1
8 26577016 Disruption of S2-M4 linker coupling reveals novel subunit-specific contributions to N-methyl-d-aspartate receptor function and ethanol sensitivity. 2016 Jun 1
9 27618671 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. 2016 Sep 21 1
10 25544544 Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine. 2015 Jan 27 1
11 25964432 Glycine-dependent activation of NMDA receptors. 2015 Jun 1
12 23089362 Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects. 2013 Apr 1
13 23909910 Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. 2013 Aug 22 1
14 24048732 N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation. 2013 Dec 1 1
15 21735122 Evaluation of natural and nitramine binding energies to 3-D models of the S1S2 domains in the N-methyl-D-aspartate receptor. 2012 Apr 1
16 22715100 Interactions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-methyl-D-aspartate receptor forming sites of alcohol action. 2012 Aug 10 1
17 20810618 Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. 2010 Dec 2
18 17403555 Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. 2007 May 1
19 17878266 The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. 2007 Dec 2
20 18073551 Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. 2007 Nov 2
21 16417568 Protein kinase C enhances glycine-insensitive desensitization of NMDA receptors independently of previously identified protein kinase C sites. 2006 Mar 1
22 15650113 Molecular determinants of glycine-independent desensitization of NR1/NR2A receptors. 2005 May 4
23 15970596 Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. 2005 Aug 19 1
24 16281028 Subunit arrangement and function in NMDA receptors. 2005 Nov 10 1
25 14722247 Site within N-Methyl-D-aspartate receptor pore modulates channel gating. 2004 Jan 1
26 12068077 Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating. 2002 Jun 3
27 11572853 Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. 2001 Nov 30 1
28 11754839 Intersubunit cooperativity in the NMDA receptor. 2001 Dec 20 1
29 10780999 Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists. 2000 May 2
30 10208572 NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia. 1999 Feb 25 1
31 9481670 Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+. 1998 Jan 1 1
32 9491993 Glycine-independent NMDA receptor desensitization: localization of structural determinants. 1998 Feb 1
33 9729615 Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones. 1998 Oct 1 1
34 9312102 The NR2B-specific interactions of polyamines and protons with the N-methyl-D-aspartate receptor. 1997 Oct 3 1
35 9375665 Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells. 1997 Dec 2
36 8632186 Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites. 1996 Jun 1
37 7476914 Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. 1995 Nov 1
38 7528680 Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition. 1994 Aug 16 1
39 7903167 Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. 1993 Sep 30 1