sulforaphane

kelch like ECH associated protein 1 ; Homo sapiens







34 Article(s)
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1 35041848 Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling. 2022 Apr 1
2 31721705 In Silico Drug-designing Studies on Sulforaphane Analogues: Pharmacophore Mapping, Molecular Docking and QSAR Modeling. 2021 2
3 32492957 AOP1, a New Live Cell Assay for the Direct and Quantitative Measure of Intracellular Antioxidant Effects. 2020 Jun 1 1
4 30528536 Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. 2019 Jan 1
5 29305271 Sulforaphane and 5-fluorouracil synergistically inducing autophagy in breast cancer: A possible role for the Nrf2-Keap1-ARE signaling? 2018 Feb 1
6 27889639 Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. 2017 Apr 3
7 29242678 KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. 2017 Nov 1
8 26970133 Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. 2016 Feb 1
9 24352536 The broccoli-born isothiocyanate sulforaphane impairs nucleotide excision repair: XPA as one potential target. 2014 Mar 1
10 24416372 SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. 2014 1
11 24871574 Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. 2014 May 27 1
12 22752583 Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. 2013 2
13 23581983 Keap1-Nrf2 signaling pathway: mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles. 2013 Feb 1
14 23589329 Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. 2013 Jun 2
15 23843041 Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. 2013 Nov 2
16 22303412 Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. 2012 1
17 22578879 Glucosinolates and isothiocyanates in health and disease. 2012 Jun 1
18 22776248 Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2. 2012 Sep 15 1
19 21391649 Modification of keap1 cysteine residues by sulforaphane. 2011 Apr 18 5
20 21793854 Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. 2011 Jul 2
21 20486933 Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1. 2010 May 2
22 20599909 Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2). 2010 Sep 25 1
23 18407246 Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. 2008 Jun 1 1
24 18417180 Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. 2008 Aug 1 1
25 17028159 The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. 2007 Jan 1
26 16520150 Chemoprotection by sulforaphane: keep one eye beyond Keap1. 2006 Feb 28 2
27 16951197 Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. 2006 Sep 1 2
28 17046835 PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. 2006 Dec 8 1
29 15826493 Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. 2005 Mar 31 1
30 15923610 The GI-GPx gene is a target for Nrf2. 2005 Jun 5
31 16006525 Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. 2005 Jul 19 1
32 16359182 Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. 2005 Dec 10
33 15572695 Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. 2004 Dec 3
34 14585973 Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. 2003 Nov 3