Aspartic Acid

caspase 3 ; Homo sapiens







70 Article(s)
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1 33807852 Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment. 2021 Mar 5 1
2 34037204 Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7. 2021 Jun 25 1
3 31117169 Design of a Human Rhinovirus-14 3C Protease-Inducible Caspase-3. 2019 May 21 1
4 29909197 Plasmonic Au nanostar Raman probes coupling with highly ordered TiO2/Au nanotube arrays as the reliable SERS sensing platform for chronic myeloid leukemia drug evaluation. 2018 Oct 15 2
5 28653316 Structural basis for alpha fetoprotein-mediated inhibition of caspase-3 activity in hepatocellular carcinoma cells. 2017 Oct 1 1
6 27168077 Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells. 2016 1
7 27882936 The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. 2016 Nov 24 1
8 26511318 Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid. 2015 Dec 18 4
9 23150525 Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases. 2013 Feb 4
10 23345589 Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis. 2013 Mar 1
11 23386603 Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. 2013 Apr 5 1
12 23754197 Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model. 2013 Aug 1
13 24226268 Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. 2013 Dec 1
14 24349509 Cadmium induces liver cell apoptosis through caspase-3A activation in purse red common carp (Cyprinus carpio). 2013 1
15 22143383 Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles. 2012 Jan 25 2
16 22294086 Monitoring cleaved caspase-3 activity and apoptosis of immortalized oligodendroglial cells using live-cell imaging and cleaveable fluorogenic-dye substrates following potassium-induced membrane depolarization. 2012 Jan 13 2
17 22461642 Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. 2012 Mar 28 1
18 21416616 Aminoluciferins as functional bioluminogenic substrates of firefly luciferase. 2011 Jul 4 1
19 21821879 In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety. 2011 Aug 1 1
20 20528251 Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway. 2010 Jul 2
21 20541849 Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. 2010 Sep 1
22 19283487 Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. 2009 May 2
23 19342873 The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers. 2009 May 1 1
24 19685303 Detection of apoptosis using cyclic luciferase in living mammals. 2009 1
25 17989718 Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. 2008 Feb 1
26 18434077 The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells. 2008 Aug 1
27 18586680 Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. 2008 Aug 29 1
28 18775457 A potent reporter applicable to the monitoring of caspase-3-dependent proteolytic cleavage. 2008 Nov 6 1
29 18854175 Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation. 2008 Dec 19 1
30 17178732 Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration. 2007 Feb 23 2
31 17379327 Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9. 2007 Jun 2
32 17437405 Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. 2007 Jul 1 1
33 16286477 The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. 2006 Feb 10 1
34 16420423 Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. 2006 Jan 2
35 16023344 Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors. 2005 Sep 1 1
36 16038904 The co-chaperone p23 is degraded by caspases and the proteasome during apoptosis. 2005 Aug 1 1
37 14599290 AlphaII-spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding. 2004 Feb 15 1
38 14729472 Correlation between nucleocytoplasmic transport and caspase-3-dependent dismantling of nuclear pores during apoptosis. 2004 Feb 15 1
39 15087450 Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis. 2004 Jun 25 1
40 20642015 Cy5-Tat-Glu-Pro-Asp-acyloxymethyl ketone 2004 1
41 12660222 Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. 2003 Apr 2
42 12821118 Caspase-mediated cleavage of JNK during stress-induced apoptosis. 2003 Jul 11 1
43 14559822 Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma. 2003 Oct 1 1
44 14628683 DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet. 2003 Nov 2
45 14705865 Chemical-induced apoptosis: formation of the Apaf-1 apoptosome. 2003 Nov 3
46 11875078 Caspase proteolysis of the cohesin component RAD21 promotes apoptosis. 2002 May 10 1
47 12145294 Asp1080 upstream of the calmodulin-binding domain is critical for autoinhibition of hPMCA4b. 2002 Sep 27 1
48 11230124 Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. 2001 Mar 1 1
49 11320092 Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis. 2001 Jul 6 1
50 11325591 The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. 2001 Apr 1