Bortezomib

caspase 3 ; Homo sapiens







73 Article(s)
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1 33376542 Inhibition of autophagy enhances apoptosis induced by bortezomib in AML cells. 2021 Feb 1
2 33609728 Evaluation of Virola oleifera activity in musculoskeletal pathologies: Inhibition of human multiple myeloma cells proliferation and combination therapy with dexamethasone or bortezomib. 2021 May 23 1
3 32551032 BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis. 2020 1
4 32868799 Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro. 2020 Aug 31 1
5 33191863 Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway. 2020 Dec 1
6 31392596 G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis. 2019 Sep 1
7 31631595 [Bortezomib Inhibits Extranodal Natural Killer/T Cell Lymphoma, Nasal Type by Targeting NF-κB Signaling Pathway]. 2019 May 1
8 29349597 Drug repurposing screening identifies bortezomib and panobinostat as drugs targeting cancer associated fibroblasts (CAFs) by synergistic induction of apoptosis. 2018 Aug 1
9 30338762 Cobalt chloride affects the death of SH-SY5Y cells induced by inhibition of ubiquitin proteasome system. Role of heat shock protein 70 and caspase 3. 2018 Oct 19 1
10 28487980 Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia. 2017 Jul 1
11 28725954 Proteasome Stress Triggers Death of SH-SY5Y and T98G Cells via Different Cellular Mechanisms. 2017 Nov 2
12 28869453 Bortezomib could down-regulate the expression of RANKL, inhibit cell proliferation and induce cell apoptosis in the human myeloma cell line RPMI 8226 by activating casepase-3. 2017 Aug 23 2
13 29070119 [Anti-proliferation Effect of NS-398 in Combination with Bortezomib on Multiple Myeloma RPMI 8226 Cells In Vitro]. 2017 Oct 1
14 29161153 Protective effects of agomelatine on testicular damage caused by bortezomib. 2017 1
15 27863383 Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy. 2016 Dec 27 1
16 27995884 [Study of the effects in vitro of berberine combined with bortezomib on multiple myeloma cell line U266 cells]. 2016 Nov 14 1
17 25367763 Differential impact of bortezomib on HL-60 and K562 cells. 2015 Jan 1
18 25602436 Bortezomib inhibits gastric carcinoma HGC-27 cells through the phospho-Jun N-terminal kinase (p-JNK) pathway in vitro. 2015 Apr 1 1
19 25812695 Mcl-1 downregulation sensitizes glioma to bortezomib-induced apoptosis. 2015 May 1
20 25995634 Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells. 2015 1
21 26165741 Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells. 2015 Dec 1
22 26171069 Synergistic effects of cisplatin and proteasome inhibitor bortezomib on human bladder cancer cells. 2015 Jul 2
23 26254608 The proapoptotic protein Bim is up regulated by 1α,25-dihydroxyvitamin D3 and its receptor agonist in endothelial cells and transformed by viral GPCR associated to Kaposi sarcoma. 2015 Oct 1
24 26544558 Synergistic Effect and Molecular Mechanism of Homoharringtonine and Bortezomib on SKM-1 Cell Apoptosis. 2015 1
25 26622468 Bortezomib inhibits cell proliferation in prostate cancer. 2015 Sep 1
26 24706190 Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells. 2014 Jun 1
27 24854658 Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. 2014 May 9 1
28 25323693 Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. 2014 Nov 2
29 23025401 Changes in protein profiles of multiple myeloma cells in response to bortezomib. 2013 May 1
30 23079083 Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells. 2013 Jan 2
31 23698252 Bortezomid enhances the efficacy of lidamycin against human multiple myeloma cells. 2013 Jul 1
32 24093630 Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis. 2013 Dec 2
33 24155950 Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells. 2013 1
34 24156429 [Effect of PCI-32765 and bortezomib on proliferation and apoptosis of B-cell tumor cell lines and its mechanisms]. 2013 Oct 1
35 24377552 Effects of arsenic trioxide alone and in combination with bortezomib in multiple myeloma RPMI 8266 cells. 2013 1
36 21978467 Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. 2012 Feb 1
37 22006286 Targeting the proteasome as a promising therapeutic strategy in thyroid cancer. 2012 Mar 15 1
38 22262760 Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. 2012 Mar 15 1
39 22313636 Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor. 2012 Apr 1
40 22391178 Effects of arsenic trioxide combined with bortezomib on apoptosis of multiple myeloma cell line KM3 and its mechanisms. 2012 Feb 3
41 22436457 Synthetic lethal screen identifies NF-κB as a target for combination therapy with topotecan for patients with neuroblastoma. 2012 Mar 21 1
42 22477151 Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer. 2012 Dec 1
43 22739154 [Effect of bortezomib and low concentration cytarabine on apoptosis in U937 cell line]. 2012 Jun 1
44 21174067 Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress. 2011 Mar 2
45 21195056 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. 2011 Feb 4 1
46 21448923 Modulation of the tumor cell death pathway by androgen receptor in response to cytotoxic stimuli. 2011 Nov 1
47 21518486 [NB4 cell apoptosis induced by bortezomib combined with As(2)O(3) and its mechanism]. 2011 Apr 3
48 19800672 Proteasome inhibitor bortezomib increases radiation sensitivity in androgen independent human prostate cancer cells. 2010 Apr 1
49 20150630 The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. 2010 Jan 1
50 20378569 Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells. 2010 Sep 1