Title : Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1.

Pub. Date : 2011 Feb 4

PMID : 21195056






1 Functional Relationships(s)
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1 Coexposure of K562 or chronic myeloid leukemia (CML) cells from patients to subtoxic concentrations of SKI (10 muM) and bortezomib (100 nM) resulted in a synergistic increase in caspase-3 cleavage and apoptosis. Bortezomib caspase 3 Homo sapiens