Dopamine

synuclein, alpha ; Mus musculus







109 Article(s)
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1 34806235 Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology. 2022 Mar 4
2 35038583 Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype. 2022 Apr 6 2
3 35075150 MicroRNA-181a-2-3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and NOX4. 2022 Jan 24 1
4 35163729 Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice. 2022 Feb 4 1
5 35214176 Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson's Disease. 2022 Feb 18 1
6 35280925 Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. 2022 Jun 14 1
7 33429895 Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons. 2021 Jan 8 3
8 33713002 Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. 2021 Apr 3
9 33727096 An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease. 2021 Jul 1
10 33805843 Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice. 2021 Mar 13 2
11 33935654 Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol. 2021 8
12 34083630 Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. 2021 Jun 3 1
13 34307368 Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus. 2021 1
14 34408150 α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. 2021 Aug 18 3
15 34509608 A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. 2021 Nov 1
16 34716339 Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity. 2021 Oct 29 1
17 31768670 Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. 2020 Feb 1
18 31837424 Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions. 2020 Feb 1
19 32865008 IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER. 2020 Oct 1 1
20 32865527 Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons. 2020 Aug 16 5
21 32964492 GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. 2020 Dec 3
22 30496735 Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization. 2019 Mar 15 2
23 30592597 Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration. 2019 Feb 20 3
24 30633814 The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration. 2019 Feb 3
25 30741691 The Amphetamine Induced Rotation Test: A Re-Assessment of Its Use as a Tool to Monitor Motor Impairment and Functional Recovery in Rodent Models of Parkinson's Disease. 2019 1
26 30890737 Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice. 2019 Mar 19 1
27 31165254 Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. 2019 Oct 1
28 31420910 Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein. 2019 Dec 2
29 31445131 Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway. 2019 Dec 5 1
30 29524599 A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P. 2018 Jun 1
31 29559809 The Convergence of Dopamine and α-Synuclein: Implications for Parkinson's Disease. 2018 6
32 29785351 Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain. 2018 2
33 30127535 α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies. 2018 Aug 20 1
34 30127714 Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain. 2018 1
35 30503521 Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. 2018 Dec 6 1
36 30622456 Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson's Disease and Diabetes as Well as Potential Therapies? 2018 1
37 28053029 Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. 2017 Jan 4 1
38 28637871 Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. 2017 Aug 25 1
39 28920936 Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. 2017 Nov 4
40 29200905 MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation. 2017 Nov 1
41 26880341 The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease. 2016 May 1 1
42 27161373 Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain. 2016 Aug 2
43 27614017 Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism. 2016 Oct 1
44 25446742 Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms. 2015 Feb 15 4
45 25500798 The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity. 2015 1
46 25567480 Protein phosphatase 2A is involved in the tyrosine hydroxylase phosphorylation regulated by α-synuclein. 2015 Mar 1
47 25714663 Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease. 2015 1
48 25852303 Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. 2015 1
49 25853296 PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein. 2015 Apr 1 1
50 25967550 α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons. 2015 Jul 1 4