2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mechanistic target of rapamycin kinase ; Rattus norvegicus







30 Article(s)
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1 35438806 Poly(I:C) attenuates myocardial ischemia/reperfusion injury by restoring autophagic function. 2022 May 3
2 35489106 Vaspin contributes to autophagy and endothelial-to-mesenchymal transition via PI3K-/AKT-mTOR pathway. 2022 May 1
3 34082015 Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway. 2021 Oct 5 1
4 34306372 Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway. 2021 1
5 34955724 Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses. 2021 1
6 32150791 Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy. 2020 Apr 1
7 32179193 4-PBA Enhances Autophagy by Inhibiting Endoplasmic Reticulum Stress in Recombinant Human Beta Nerve Growth Factor-Induced PC12 cells After Mechanical Injury via PI3K/AKT/mTOR Signaling Pathway. 2020 Jun 1
8 32508639 Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension. 2020 1
9 30569126 Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats. 2019 Feb 1
10 30838711 Ganoderic acid A alleviates hypoxia-induced apoptosis, autophagy, and inflammation in rat neural stem cells through the PI3K/AKT/mTOR pathways. 2019 May 1
11 30880910 Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress. 2019 3
12 31265179 Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation. 2019 Oct 1
13 31351473 Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. 2019 Jul 27 1
14 31461309 Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model. 2019 Oct 1
15 31806860 Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. 2019 Dec 6 1
16 29696512 Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic-Ischemic Brain Injury. 2018 Jun 1
17 30459239 Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture. 2018 Dec 21 1
18 27760741 Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway. 2017 Jan 1
19 27217295 Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats. 2016 Sep 1
20 24375611 Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a. 2014 May 1
21 24949720 mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection. 2014 1
22 23635649 Isoflurane preconditioning increases survival of rat skin random-pattern flaps by induction of HIF-1α expression. 2013 1
23 23142719 Alpha-crystallin promotes rat olfactory ensheathing cells survival and proliferation through regulation of PI3K/Akt/mTOR signaling pathways. 2012 Dec 7 1
24 21073857 Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells. 2011 Jun 1
25 20389030 VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway. 2010 1
26 18983912 GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner. 2009 Feb 1
27 18374201 Role of growth arrest-specific gene 6 in diabetic nephropathy. 2008 1
28 16820027 Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. 2006 Jun 1
29 14660591 Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. 2004 Mar 5 1
30 12217904 Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. 2002 Oct 1