Title : Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a.

Pub. Date : 2014 May

PMID : 24375611






1 Functional Relationships(s)
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1 Western blot assay showed that, after treatment with simvastatin, the phosphorylation of Akt/mTOR/p70 S6K and FoxO3a were up-regulated in rapamycin-induced CMECs, which was significantly reversed by pretreatment with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mechanistic target of rapamycin kinase Rattus norvegicus