SCH772984

mitogen-activated protein kinase 3 ; Homo sapiens







28 Article(s)
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1 35514314 Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state. 2022 Jun 1
2 33258389 GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. 2021 Dec 2
3 33595872 Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo. 2021 Mar 1
4 33807122 Antitumoral Activity of the MEK Inhibitor Trametinib (TMT212) Alone and in Combination with the CDK4/6 Inhibitor Ribociclib (LEE011) in Neuroendocrine Tumor Cells In Vitro. 2021 Mar 23 1
5 33816264 TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway. 2021 1
6 33816301 Targeting the MDSCs of Tumors In Situ With Inhibitors of the MAPK Signaling Pathway to Promote Tumor Regression. 2021 1
7 34062009 miR-506-loaded gelatin nanospheres target PENK and inactivate the ERK/Fos signaling pathway to suppress triple-negative breast cancer aggressiveness. 2021 Aug 1
8 34610960 DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway. 2021 Dec 1
9 34697988 EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity. 2021 Oct 26 2
10 34770830 Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP+-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease. 2021 Oct 24 1
11 32576853 Genome-wide DNA methylation analysis of KRAS mutant cell lines. 2020 Jun 23 1
12 32705806 Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells. 2020 Sep 1
13 30361508 Increased invasive phenotype of CSF-1R expression in glioma cells via the ERK1/2 signaling pathway. 2019 May 1
14 30362626 lncRNA DRHC inhibits proliferation and invasion in hepatocellular carcinoma via c-Myb-regulated MEK/ERK signaling. 2019 Mar 1
15 30426301 Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. 2019 May 1
16 30754024 Incorporation of cerium oxide in hollow mesoporous bioglass scaffolds for enhanced bone regeneration by activating the ERK signaling pathway. 2019 Mar 28 1
17 30899402 JQ1 effectively inhibits vasculogenic mimicry of pancreatic ductal adenocarcinoma cells via the ERK1/2-MMP-2/9 signaling pathway both in vitro and in vivo. 2019 2
18 31031847 The Down-Regulation of SUZ12 Accelerates the Migration and Invasion of Liver Cancer Cells via Activating ERK1/2 Pathway. 2019 1
19 29733883 Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells. 2018 Aug 1
20 29888601 Javamide-II Found in Coffee Is Better than Caffeine at Suppressing TNF-α Production in PMA/PHA-Treated Lymphocytic Jurkat Cells. 2018 Jul 5 1
21 30213106 Newcastle Disease Virus V Protein Promotes Viral Replication in HeLa Cells through the Activation of MEK/ERK Signaling. 2018 Sep 12 1
22 30568786 Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. 2018 Dec 7 2
23 28821612 Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cγ-mediated FAK/ERK signaling pathway in colon cancer. 2017 Sep 29 1
24 26832798 Dissecting Therapeutic Resistance to ERK Inhibition. 2016 Apr 3
25 25142146 Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma. 2014 Aug 20 2
26 25195011 A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. 2014 Oct 3
27 23614898 Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 2013 Jul 2
28 23847348 ERK pathway inhibitors: how low should we go? 2013 Jul 1