Pub. Date : 2013 Jul
PMID : 23614898
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we describe the identification and characterization of SCH772984, a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors. | SCH772984 | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Importantly, SCH772984 effectively inhibited MAPK signaling and cell proliferation in BRAF or MEK inhibitor-resistant models as well as in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors. | SCH772984 | mitogen-activated protein kinase 3 | Homo sapiens |