| 1 |
35412944 | Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway. | 2022 Apr |
1 |
| 2 |
34240493 | Persistent activation of the mammalian target of rapamycin signalling pathway in cutaneous squamous cell carcinomas in cats. | 2021 Dec |
2 |
| 3 |
34515904 | Management of hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer. | 2021 Nov |
1 |
| 4 |
31707337 | Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. | 2020 Jan |
1 |
| 5 |
31734375 | Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway. | 2020 May |
1 |
| 6 |
31884041 | Phosphoproteomic analysis reveals Akt isoform-specific regulation of cytoskeleton proteins in human temporal lobe epilepsy with hippocampal sclerosis. | 2020 Mar |
1 |
| 7 |
31902939 | Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway. | 2020 Jan 6 |
1 |
| 8 |
31931659 | Autophagy drives fibroblast senescence through MTORC2 regulation. | 2020 Nov |
1 |
| 9 |
31955800 | Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. | 2020 Jan |
2 |
| 10 |
31989480 | Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia. | 2020 Feb |
2 |
| 11 |
32031889 | MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial. | 2020 Apr 1 |
1 |
| 12 |
32743074 | Increased PIP3 activity blocks nanoparticle mRNA delivery. | 2020 Jul |
2 |
| 13 |
32843426 | Dual inhibition of BRAF and mTOR in BRAF V600E -mutant pediatric, adolescent, and young adult brain tumors. | 2020 Aug |
1 |
| 14 |
30574817 | Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer. | 2019 Feb |
2 |
| 15 |
30735452 | lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. | 2019 Apr 1 |
2 |
| 16 |
31541079 | DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. | 2019 Sep 20 |
2 |
| 17 |
31553879 | Preclinical Evaluation of a Fluorine-18 (18F)-Labeled Phosphatidylinositol 3-Kinase Inhibitor for Breast Cancer Imaging. | 2019 Nov 4 |
2 |
| 18 |
31649622 | Role of mTOR Signaling in Female Reproduction. | 2019 |
2 |
| 19 |
31662455 | Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. | 2019 Oct 29 |
1 |
| 20 |
31684190 | Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression. | 2019 Nov 3 |
2 |
| 21 |
29360358 | Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma. | 2018 Feb 22 |
1 |
| 22 |
29428962 | Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. | 2018 Feb 11 |
1 |
| 23 |
28528184 | Synergistic antitumor effect of NVP-BEZ235 and CAPE on MDA-MB-231 breast cancer cells. | 2017 Aug |
2 |
| 24 |
28627412 | Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression. | 2017 Aug |
2 |
| 25 |
29067015 | Serum Metabolic Alterations upon Zika Infection. | 2017 |
1 |
| 26 |
25801978 | Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia. | 2015 |
2 |
| 27 |
25870799 | Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer. | 2015 Apr |
1 |
| 28 |
24782230 | Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum. | 2014 Jul |
1 |
| 29 |
23630012 | Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. | 2013 Jun |
2 |
| 30 |
23684942 | Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. | 2013 Sep |
1 |
| 31 |
22358332 | PI3K signalling: the path to discovery and understanding. | 2012 Feb 23 |
1 |
| 32 |
23369283 | Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer. | 2012 Nov 15 |
1 |
| 33 |
21536148 | Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IκB kinase activity. | 2011 Aug |
2 |
| 34 |
21715609 | An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome. | 2011 Jun 29 |
1 |
| 35 |
19561084 | Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. | 2009 Aug 21 |
1 |
| 36 |
19703998 | Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation. | 2009 Nov |
2 |
| 37 |
18660503 | Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb. | 2008 Sep 26 |
1 |
| 38 |
17203200 | The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. | 2007 Feb |
2 |
| 39 |
17289850 | Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. | 2007 May |
1 |
| 40 |
16354680 | Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. | 2006 Jan |
2 |
| 41 |
15576463 | Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. | 2005 Mar |
1 |
| 42 |
16036916 | Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. | 2005 Sep 16 |
1 |
| 43 |
16176982 | Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. | 2005 Oct 4 |
2 |
| 44 |
14982927 | Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. | 2004 May 7 |
2 |
| 45 |
14623952 | Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. | 2003 Nov 25 |
2 |
| 46 |
12374276 | Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. | 2002 |
1 |
| 47 |
12622421 | Translational control of protein synthesis in pancreatic acinar cells. | 2002 |
1 |
| 48 |
10972980 | Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. | 2000 Sep 7 |
1 |
| 49 |
8895571 | Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. | 1996 Oct 1 |
1 |