Crizotinib

mechanistic target of rapamycin kinase ; Homo sapiens







10 Article(s)
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1 34729938 Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer. 2021 Dec 2
2 33082316 Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma. 2020 Oct 20 2
3 29755689 A subgroup of pleural mesothelioma expresses ALK protein and may be targetable by combined rapamycin and crizotinib therapy. 2018 Apr 17 2
4 30466782 Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer. 2018 Dec 9 1
5 28845578 Patient harboring a novel PIK3CA point mutation after acquired resistance to crizotinib in an adenocarcinoma with ROS1 rearrangement: A case report and literature review. 2017 Nov 2
6 29383132 Norcantharidin alone or in combination with crizotinib induces autophagic cell death in hepatocellular carcinoma by repressing c-Met-mTOR signaling. 2017 Dec 29 2
7 24556908 Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer. 2014 May 1
8 24929890 Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma. 2014 Aug 2
9 25228590 Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma. 2014 Sep 30 1
10 22987955 Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas. 2012 Sep 1