2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mechanistic target of rapamycin kinase ; Homo sapiens







155 Article(s)
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1 32762281 MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway. 2022 Feb 1
2 34913077 AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway. 2022 Feb 1
3 34958867 Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells. 2022 Mar 1
4 35149293 IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation. 2022 May 1
5 35176991 Fangchinoline inhibited proliferation of neoplastic B-lymphoid cells and alleviated Sjögren's syndrome-like responses in NOD/Ltj mice via the Akt/mTOR pathway. 2022 Feb 17 1
6 35352734 Glucosamine enhances proliferation, barrier, and anti-oxidative functions in porcine trophectoderm cells. 2022 Apr 20 1
7 35602302 Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway. 2022 1
8 32900356 Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway. 2021 Oct 25 1
9 33227289 Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells. 2021 Jan 15 2
10 33269749 Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury. 2021 Jun 1
11 33627540 Arctigenin Triggers Apoptosis and Autophagy via PI3K/Akt/mTOR Inhibition in PC-3M Cells. 2021 May 1 1
12 33681258 Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways. 2021 1
13 34001063 PI3K/AKT/mTOR signaling participates in insulin-mediated regulation of pathological myopia-related factors in retinal pigment epithelial cells. 2021 May 17 1
14 34399087 Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells. 2021 Oct 2
15 34552006 Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance. 2021 Dec 1
16 34771123 Harmine Hydrochloride Mediates the Induction of G2/M Cell Cycle Arrest in Breast Cancer Cells by Regulating the MAPKs and AKT/FOXO3a Signaling Pathways. 2021 Nov 5 1
17 34938752 Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants. 2021 1
18 31586300 mTOR inhibitor everolimus reduces invasiveness of melanoma cells. 2020 Jan 2
19 31605630 Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy. 2020 Jan 1
20 31746379 Mechanical stress promotes biological functions of C2C12 myoblasts by activating PI3K/AKT/mTOR signaling pathway. 2020 Jan 1
21 31748028 Gambogic Acid Affects Ribosomal Occurrence in Glioma Cells by Downregulating the Phosphoinositide Kinase-3/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway. 2020 Jun 1 1
22 31931659 Autophagy drives fibroblast senescence through MTORC2 regulation. 2020 Nov 1
23 31974627 CYP2E1 changes the biological function of gastric cancer cells via the PI3K/Akt/mTOR signaling pathway. 2020 Feb 1
24 32016453 Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. 2020 Mar 1
25 32033754 CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. 2020 Apr 9 1
26 32458975 SIK2 Promotes Cisplatin Resistance Induced by Aerobic Glycolysis in Breast Cancer Cells through PI3K/AKT/mTOR Signaling Pathway. 2020 May 27 1
27 32926102 S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway. 2020 Sep 1 1
28 33291082 AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1. 2020 Dec 3 1
29 30260006 Pingchuanning decoction attenuates airway inflammation by suppressing autophagy via phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in rat models of asthma. 2019 Mar 1
30 30421162 Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. 2019 Aug 1
31 30584986 Knockdown of inhibitor of differentiation 1 suppresses proliferation and induces apoptosis by inactivating PI3K/Akt/mTOR signaling in hemangioma-derived endothelial cells. 2019 Mar 1
32 30737086 PI3K inhibitors protect against glucocorticoid-induced skin atrophy. 2019 Mar 1
33 31228450 Anti-tumor efficacy of phellamurin in osteosarcoma cells: Involvement of the PI3K/AKT/mTOR pathway. 2019 Sep 5 1
34 31340906 [Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway]. 2019 Jul 30 1
35 31658358 miR-365 inhibits duck myoblast proliferation by targeting IGF-I via PI3K/Akt pathway. 2019 Nov 29 1
36 29115424 Cornin protects SH‑SY5Y cells against oxygen and glucose deprivation‑induced autophagy through the PI3K/Akt/mTOR pathway. 2018 Jan 1
37 29377505 Maternal diabetes up-regulates NOX2 and enhances myocardial ischaemia/reperfusion injury in adult offspring. 2018 Apr 1
38 29386059 MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma. 2018 Jan 31 1
39 29402343 MicroRNA-204 Inhibits the Growth and Motility of Colorectal Cancer Cells by Downregulation of CXCL8. 2018 Sep 14 2
40 29435149 MiR-361-5p suppresses chemoresistance of gastric cancer cells by targeting FOXM1 via the PI3K/Akt/mTOR pathway. 2018 Jan 12 1
41 29488612 Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells. 2018 May 3
42 29524402 Ghrelin promotes human non-small cell lung cancer A549 cell proliferation through PI3K/Akt/mTOR/P70S6K and ERK signaling pathways. 2018 Apr 6 1
43 29556265 Advanced oxidation protein products inhibit the autophagy of renal tubular epithelial cells. 2018 Apr 2
44 29708815 PI3K/AKT/mTOR pathway inhibitors inhibit the growth of melanoma cells with mTOR H2189Y mutations in vitro. 2018 Jul 3 1
45 29709474 Keratinocyte growth factor protects endometrial cells from oxygen glucose deprivation/re-oxygenation via activating Nrf2 signaling. 2018 Jun 18 1
46 30119206 Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma. 2018 Oct 1
47 30195142 Overexpression of T-cadherin inhibits the proliferation of oral squamous cell carcinoma through the PI3K/AKT/mTOR intracellular signalling pathway. 2018 Dec 1
48 30208576 Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway. 2018 Sep 11 2
49 33052635 Thioridazine upregulates programmed cell death 4 to induce apoptosis in nasopharyngeal carcinoma through the PI3K/Akt signalling pathway. 2018 Feb 1
50 28193579 Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells. 2017 May 1