Reactive Oxygen Species

mechanistic target of rapamycin kinase ; Homo sapiens







166 Article(s)
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1 34904613 Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin. 2022 Jan 4 1
2 35204299 Impact of Seminal Plasma Antioxidants on Donkey Sperm Cryotolerance. 2022 Feb 18 1
3 35204748 Inflammation Promotes Oxidative and Nitrosative Stress in Chronic Myelogenous Leukemia. 2022 Feb 3 1
4 35394351 Graphene oxide induces autophagy and apoptosis via the ROS-dependent AMPK/mTOR/ULK-1 pathway in colorectal cancer cells. 2022 Apr 2
5 35635082 Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells. 2022 May 1
6 35636015 TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling. 2022 Jul 2
7 33314691 Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy. 2021 Feb 1
8 33704260 Retracted: Inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive Oxygen Species (ROS) Production, and Autophagy Induction. 2021 Mar 11 3
9 33791802 Cytotoxicity mechanisms of plumbagin in drug-resistant tongue squamous cell carcinoma. 2021 Mar 1 1
10 33845796 Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling. 2021 Apr 12 2
11 34091997 AQP3-mediated H2 O2 uptake inhibits LUAD autophagy by inactivating PTEN. 2021 Aug 1
12 34094961 Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer. 2021 3
13 34278450 Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. 2021 Sep 2
14 34302638 Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells. 2021 Jul 1
15 34367466 Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy. 2021 1
16 34461258 SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. 2021 Dec 1 3
17 34503074 Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells. 2021 Aug 24 1
18 34580235 Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells. 2021 Sep 27 1
19 34687671 A novel biphenyl diester derivative, AB38b, inhibits glioblastoma cell growth via the ROS-AKT/mTOR pathway. 2021 Dec 1
20 34832864 Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma. 2021 Oct 26 2
21 34950150 Oxidative Stress Promotes Instability of Regulatory T Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 2021 1
22 34954677 Bisphenol A induces apoptosis and autophagy in murine osteocytes MLO-Y4: Involvement of ROS-mediated mTOR/ULK1 pathway. 2021 Dec 23 2
23 35126111 FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway. 2021 1
24 31996020 Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. 2020 Mar 2
25 32016465 Low‑intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS‑miR‑21‑PTEN axis. 2020 Mar 1
26 32021099 Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2-ROS-Mediated Pro-Survival Signal Pathways. 2020 1
27 32097729 ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells. 2020 May 2
28 32141450 Initiation of protective autophagy in hepatocytes by gold nanorod core/silver shell nanostructures. 2020 Mar 21 1
29 32235006 Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. 2020 Apr 1 2
30 32275808 ROS accumulation contributes to abamectin-induced apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway in TM3 Leydig cells. 2020 Aug 1
31 32476238 Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. 2020 Jul 1
32 32605589 BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. 2020 Jun 30 1
33 32687921 α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway. 2020 Sep 15 2
34 32795289 HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway. 2020 Aug 14 2
35 32910941 IL-6-induced acetylation of E2F1 aggravates oxidative damage of retinal pigment epithelial cell line. 2020 Nov 1
36 33131385 Reactive Oxygen Species Secreted by Leukocytes in Semen Induce Self-Expression of Interleukin-6 and Affect Sperm Quality. 2020 Sep-Oct 2
37 33293849 Reactive Oxygen Species: Drivers of Physiological and Pathological Processes. 2020 1
38 33377662 Combinational therapy targeting the MET-mTOR-ROS loop disrupts mitochondrial autoregulatory machinery of liver cancer. 2020 Dec 4
39 33390956 Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway. 2020 5
40 30563887 Inhibition of Notch Signaling Enhances Chemosensitivity in B-cell Precursor Acute Lymphoblastic Leukemia. 2019 Feb 1 1
41 30569107 Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway. 2019 Feb 2
42 30651870 ROS induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy. 2019 Jan 2
43 30839155 Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia-inducible factor 1α axis. 2019 May 1
44 30896843 α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation. 2019 May 6
45 30976815 Microwave hyperthermia enhances the sensitivity of lung cancer cells to gemcitabine through reactive oxygen species‑induced autophagic death. 2019 May 1
46 31104320 IL-8 protects prostate cancer cells from GSK-3β-induced oxidative stress by activating the mTOR signaling pathway. 2019 Jul 1
47 31228582 Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. 2019 Sep 2
48 31233063 A surface-layer protein from Lactobacillus acidophilus NCFM induces autophagic death in HCT116 cells requiring ROS-mediated modulation of mTOR and JNK signaling pathways. 2019 Jul 17 2
49 31236744 Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro. 2019 Oct 2
50 31325888 BDE-209 induces autophagy and apoptosis via IRE1α/Akt/mTOR signaling pathway in human umbilical vein endothelial cells. 2019 Oct 4