Pub. Date : 2022 Jul
PMID : 35636015
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ROS production was significantly promoted and mitochondrial potential was remarkably inhibited when overexpressing TRIM22, thus activating AMPK/mTOR signaling. | Reactive Oxygen Species | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | In conclusion, our study indicated that TRIM22 inhibits OS progression by promoting proteasomal degradation of NRF2 independent of KEAP1, thereby activating ROS/AMPK/mTOR/Autophagy signaling that leads to autophagic cell death in OS. | Reactive Oxygen Species | mechanistic target of rapamycin kinase | Homo sapiens |