Paclitaxel

mitogen-activated protein kinase 8 ; Homo sapiens







72 Article(s)
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1 35239875 Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts. 2022 Feb 3
2 34457060 Role of JNK activation in paclitaxel-induced apoptosis in human head and neck squamous cell carcinoma. 2021 Oct 6
3 32594651 Paclitaxel induces apoptosis through the TAK1-JNK activation pathway. 2020 Aug 4
4 33019717 Specific c-Jun N-Terminal Kinase Inhibitor, JNK-IN-8 Suppresses Mesenchymal Profile of PTX-Resistant MCF-7 Cells through Modulating PI3K/Akt, MAPK and Wnt Signaling Pathways. 2020 Oct 1 5
5 31160603 EPHB6 mutation induces cell adhesion-mediated paclitaxel resistance via EPHA2 and CDH11 expression. 2019 Jun 3 3
6 31906029 Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells . 2019 Dec 30 6
7 29723165 Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway. 2018 May 3 3
8 30094097 Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation. 2018 3
9 26246283 Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3β-mediated B-cell lymphoma 2 regulation. 2016 Jan 2
10 26534836 Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel. 2016 Jan 4
11 26985944 Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway. 2016 Mar 11 8
12 27563006 Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. 2016 Oct 1
13 27889448 Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit. 2016 Dec 1 4
14 25351906 JNK signaling in hepatocarcinoma cells is associated with the side population upon treatment with anticancer drugs. 2015 Jan 1
15 25496994 JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. 2015 Feb 3 1
16 24787013 Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. 2014 May 1 1
17 23681233 Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation. 2013 May 16 6
18 21074392 Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells. 2012 May 8
19 22323130 Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis. 2012 May 1 2
20 22433870 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). 2012 May 18 3
21 22800348 [Role of ABCB1 and ABCG2 in the multidrug resistance of hypopharyngeal carcinoma FaDu cell line]. 2012 Apr 2
22 19944065 (-)-Epigallocatechin-3-gallate decreases thrombin/paclitaxel-induced endothelial tissue factor expression via the inhibition of c-Jun terminal NH2 kinase phosphorylation. 2010 Jan 1 2
23 20145041 Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. 2010 Feb 1
24 19048624 Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. 2009 Mar 15 3
25 19385049 Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells. 2009 Jun 1
26 19674193 Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response. 2009 Sep 2
27 19717209 Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells. 2009 Dec 2
28 17987264 Retinoids induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to taxol for apoptosis in human glioblastoma T98G and U87MG cells. 2008 Mar 2
29 18068334 Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. 2008 Feb 5
30 18341588 Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. 2008 Apr 4
31 18690538 Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells. 2008 Oct 3
32 16972069 Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity. 2007 Feb 1
33 17568772 Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1. 2007 Jul 11 1
34 16287090 Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway. 2006 Apr 15 4
35 16397234 Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. 2006 Jan 1 4
36 16547493 Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways. 2006 Aug 10 7
37 16740769 Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. 2006 Jun 1 2
38 16794185 Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-Jun terminal NH2 kinase activation. 2006 Jul 21 2
39 16969513 Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. 2006 Oct 1
40 17119350 Bcl-2 phosphorylation has pathological significance in human breast cancer. 2006 3
41 15788689 Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells. 2005 Mar 15 1
42 14500571 Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. 2004 Jan 5
43 14724588 Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. 2004 Jan 15 1
44 15001534 Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis. 2004 Jul 3
45 15467449 The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells. 2004 Oct 1
46 15467450 JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2. 2004 Oct 7
47 12510025 Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells. 2003 Apr 3
48 12555062 Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. 2003 Jan 30 2
49 12555073 An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. 2003 Jan 30 4
50 12691824 Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells. 2003 Apr 10 3