Serine

BCL2 apoptosis regulator ; Homo sapiens







98 Article(s)
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1 35177309 Corrigendum to "Anti-apoptotic genes Bcl-2 and Bcl-xL overexpression can block iridovirus serine/threonine kinase-induced Bax/mitochondria-mediated cell death in GF-1 cells" [Fish Shellfish Immunol. 61 (2017) 120-129]. 2022 Mar 1
2 33245769 Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism. 2020 Dec 16 4
3 31103719 A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression. 2019 Aug 10 2
4 30098987 Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure. 2018 Sep 1
5 27585868 Novel role of serine racemase in anti-apoptosis and metabolism. 2017 Jan 2
6 28283087 Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway. 2017 Mar 1
7 28381544 Modulation of Bax and mTOR for Cancer Therapeutics. 2017 Jun 1 1
8 25323586 Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer. 2015 May 1
9 25791820 Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways. 2015 2
10 25826088 Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87. 2015 Apr 20 2
11 25908963 A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines. 2015 1
12 26408697 CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85α Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells. 2015 Oct 1
13 26411306 Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. 2015 Sep 28 1
14 24677263 CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents. 2014 Jun 1
15 25126723 The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. 2014 Oct 1 1
16 25231749 Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. 2014 Dec 1
17 24097825 Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance. 2013 Dec 1 3
18 21993018 Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. 2012 Jan 1 1
19 22258404 ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. 2012 Jan 19 1
20 21778226 Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation. 2011 Sep 16 1
21 19866475 CCL2 is induced by chemotherapy and protects prostate cancer cells from docetaxel-induced cytotoxicity. 2010 Mar 1 1
22 20054820 Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. 2010 Jun 1 2
23 20388787 ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. 2010 Apr 15 1
24 20447425 Study of the in vivo phosphorylation of E2F1 on Ser403. 2010 Aug 1
25 20633548 Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells. 2010 Oct 25 2
26 20800695 Endoplasmic reticulum targeted Bcl2 confers long term cell survival through phosphorylation of heat shock protein 27. 2010 Dec 2
27 20808790 Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. 2010 Aug 23 1
28 20841355 Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells. 2010 Nov 26 1
29 18845789 Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. 2009 Jan 8 2
30 19029119 Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. 2009 Jan 30 4
31 19169818 Effect of hyperoxia on serine phosphorylation of apoptotic proteins in mitochondrial membranes of the cerebral cortex of newborn piglets. 2009 Jul 2
32 19539716 Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway. 2009 Sep 18 1
33 17890680 Oxidized LDL attenuates apoptosis in monocytic cells by activating ERK signaling. 2008 Jan 1
34 18367648 G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility. 2008 Aug 1
35 18596739 BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. 2008 Sep 1
36 18663430 Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. 2008 Dec 1
37 18818203 G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. 2008 Dec 5 1
38 17105820 Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. 2007 Mar 15 1
39 17637928 Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway. 2007 Jul 1
40 17696989 Reelin signals survival through Src-family kinases that inactivate BAD activity. 2007 Oct 1
41 16162358 Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. 2006 Apr 1
42 16213739 Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic injury. 2006 Mar 3
43 16219908 Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. 2006 Jan 2
44 16368533 Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. 2006 May 1 2
45 16540661 Galectin-3 regulates mitochondrial stability and antiapoptotic function in response to anticancer drug in prostate cancer. 2006 Mar 15 1
46 16636671 Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. 2006 Sep 14 1
47 16682503 Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis. 2006 Aug 1
48 17119350 Bcl-2 phosphorylation has pathological significance in human breast cancer. 2006 1
49 17145575 Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs. 2006 Nov 2
50 15817479 Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. 2005 Jun 24 1