Dopamine

catechol-O-methyltransferase ; Rattus norvegicus







71 Article(s)
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1 33503461 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain. 2021 Apr 5 4
2 33871963 Brain Microdialysis Coupled to LC-MS/MS Revealed That CVT-10216, a Selective Inhibitor of Aldehyde Dehydrogenase 2, Alters the Neurochemical and Behavioral Effects of Methamphetamine. 2021 May 5 2
3 32474681 Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility. 2020 Sep 2
4 31231499 Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats. 2019 Jun 2
5 31491076 Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors. 2019 Oct 16 3
6 32038769 Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase. 2019 Nov 14 1
7 29790069 Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model. 2018 Jul 1
8 26919286 Brain catechol-O-methyltransferase (COMT) inhibition by tolcapone counteracts recognition memory deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic mice. 2016 Aug 2
9 28066248 A Novel Sensitive Method to Measure Catechol-O-Methyltransferase Activity Unravels the Presence of This Activity in Extracellular Vesicles Released by Rat Hepatocytes. 2016 2
10 25310955 Inhibition of peripheral dopamine metabolism and the ventilatory response to hypoxia in the rat. 2015 1
11 25435314 Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation. 2015 Mar 1 2
12 24910244 Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar. 2014 Sep 1
13 23567203 Opposite effects of tolcapone on amphetamine-disrupted startle gating in low vs. high COMT-expressing rat strains. 2013 May 2
14 23613951 Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. 2013 6
15 26201931 Dopamine from cirrhotic liver contributes to the impaired learning and memory ability of hippocampus in minimal hepatic encephalopathy. 2013 Jul 2
16 22815336 Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition. 2012 Dec 3
17 20407462 Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate. 2011 Jan 2
18 22100850 Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats. 2011 Aug 2
19 19909795 Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats. 2010 Feb 3 1
20 18854987 Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex. 2009 Jan 3
21 18981694 [Role of catecholamine metabolism in blood pressure regulation using chemiluminescence reaction detection]. 2008 Nov 2
22 16352914 Role of chronic inhibition of dopamine-metabolizing enzymes in the regulation of renal sodium and phosphate excretion in the rat remnant kidney. 2006 1
23 15627800 Renal dopaminergic system activity in the rat remnant kidney. 2005 1
24 15716360 Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. 2005 Mar 1 2
25 15864503 Dopamine is metabolised by different enzymes along the rat nephron. 2005 Jun 2
26 15167541 Neuronal expression of catechol O-methyltransferase mRNA in neonatal rat suprachiasmatic nucleus. 2004 Jun 7 2
27 15190105 Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. 2004 Jun 9 1
28 12421594 Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity. 2003 Jan 1
29 12573869 Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats. 2003 Jan 3
30 12711835 Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition. 2003 Jun 1
31 11942697 Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation. 2002 Mar-Apr 6
32 11472309 Changing dopaminergic activity through different pathways: consequences for renal sodium excretion, regional blood flow and oxygen tension in the rat. 2001 Jul 1
33 11510881 The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat. 2001 Jul 4
34 10923641 Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats. 2000 Aug 1
35 10608486 Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats. 1999 Nov 1
36 10651109 Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. 1999 1
37 9460702 Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosylmethionine and S-adenosylhomocysteine in the rat brain. 1998 Jan 1
38 9597116 Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014. 1998 Apr 1
39 9622240 Dopamine turnover and metabolism in the striatum of parkinsonian rats grafted with genetically-modified human astrocytes. 1998 Jul 2
40 9085195 Peripheral and central inhibitors of catechol-O-methyl transferase: effects on liver and brain COMT activity and L-DOPA metabolism. 1997 1
41 9109519 5-hydroxy-3-ethylamino-2-oxindole is not formed in rat brain following a neurotoxic dose of methamphetamine: evidence that methamphetamine does not induce the hydroxyl radical-mediated oxidation of serotonin. 1997 May 1
42 9291195 Inhibition of COMT induces dopamine-dependent natriuresis and inhibition of proximal tubular Na+,K+-ATPase. 1997 Sep 4
43 9483396 [Microdialysis study of tolcapone effect during blockage of neuronal dopamine reuptake caused by GBR-12909]. 1997 Sep-Oct 4
44 8829199 Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats. 1996 Jun 2
45 8976015 Catechol-O-methyltransferase inhibition increases the uptake of 11C-3-(3,4-dihydroxyphenyl)-L-alanine in the rat pancreas. 1996 Dec 2
46 7542717 Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats. 1995 Jan-Feb 2
47 7570359 Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. 1995 Jul 2
48 7755845 Effects of pargyline and pyrogallol on the methamphetamine-induced dopamine depletion. 1995 Jan 1
49 8529074 Studies on the nature of the antagonistic actions of dopamine and 5-hydroxytryptamine in renal tissues. 1995 Jun 1
50 7509158 Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis. 1993 1