| 1 |
26601957 | The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin. | 2016 Jan 22 |
2 |
| 2 |
23480827 | Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa. | 2013 Apr 2 |
1 |
| 3 |
24014022 | Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides. | 2013 Oct 18 |
1 |
| 4 |
24128092 | Residues flanking scissile bonds in Factor VIII modulate rates of cleavage and proteolytic activation catalyzed by Factor Xa. | 2013 Nov 12 |
9 |
| 5 |
22411993 | Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function. | 2012 May 4 |
10 |
| 6 |
22989889 | Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism. | 2012 Nov 9 |
3 |
| 7 |
19858193 | Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate. | 2010 Jan 1 |
4 |
| 8 |
20062922 | Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity. | 2010 Jan |
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| 9 |
20722419 | Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase . | 2010 Oct 5 |
2 |
| 10 |
19010776 | Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa. | 2009 Jan 16 |
2 |
| 11 |
19172319 | A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa). | 2009 Aug |
2 |
| 12 |
19240027 | Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII. | 2009 Apr 24 |
3 |
| 13 |
19581306 | Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin. | 2009 Aug 28 |
3 |
| 14 |
18042685 | Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite. | 2008 Jan |
1 |
| 15 |
18327399 | The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase. | 2008 Mar |
1 |
| 16 |
18590276 | Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase. | 2008 Jul 29 |
2 |
| 17 |
18784085 | The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. | 2008 Nov 28 |
4 |
| 18 |
17553804 | Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. | 2007 Jul 27 |
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| 19 |
17726015 | Role of the alpha-helix 163-170 in factor Xa catalytic activity. | 2007 Oct 26 |
1 |
| 20 |
17726029 | Further evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavages. | 2007 Nov 9 |
2 |
| 21 |
17848548 | Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase. | 2007 Nov 9 |
3 |
| 22 |
17878169 | The role of thrombin exosites I and II in the activation of human coagulation factor V. | 2007 Nov 23 |
5 |
| 23 |
16454727 | Metabolism-directed optimisation of antithrombotics: the prodrug principle. | 2006 |
1 |
| 24 |
16618121 | Pentasaccharide enhances the inactivation of factor Xa by antithrombin by promoting the assembly of a Michaelis-type intermediate complex. Demonstration by rapid kinetic, surface plasmon resonance, and competitive binding studies. | 2006 Apr 25 |
1 |
| 25 |
16935856 | Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va. | 2006 Oct 20 |
8 |
| 26 |
17168727 | Arginine mimetic structures in biologically active antagonists and inhibitors. | 2006 |
3 |
| 27 |
15617517 | Ixolaris: a factor Xa heparin-binding exosite inhibitor. | 2005 May 1 |
6 |
| 28 |
16042383 | Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex. | 2005 Aug 2 |
3 |
| 29 |
15005625 | Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin. | 2004 Mar 16 |
1 |
| 30 |
15494418 | Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin. | 2004 Dec 24 |
4 |
| 31 |
12496269 | Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process. | 2003 Feb 28 |
2 |
| 32 |
12606556 | Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation. | 2003 May 9 |
1 |
| 33 |
11925440 | Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. | 2002 Jun 7 |
2 |
| 34 |
12022882 | Role of basic residues of the autolysis loop in the catalytic function of factor Xa. | 2002 May 28 |
9 |
| 35 |
12163491 | Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site. | 2002 Oct 11 |
3 |
| 36 |
12362232 | Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. | 2002 Oct |
2 |
| 37 |
10627484 | Prothrombin San Antonio: a single amino acid substitution at a factor Xa activation site (Arg320 to His) results in dysprothrombinemia. | 2000 Jan 15 |
1 |
| 38 |
10652320 | Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding. | 2000 Feb 4 |
2 |
| 39 |
11369259 | Heparin-binding exosite of factor Xa. | 2000 Nov |
1 |
| 40 |
9454596 | Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry. | 1998 Jan 27 |
1 |
| 41 |
9632668 | The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V. | 1998 Jun 26 |
3 |
| 42 |
9065469 | Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor. | 1997 Mar 21 |
2 |
| 43 |
9428662 | Proteolysis of Alzheimer's disease beta-amyloid precursor protein by factor Xa. | 1997 Nov 14 |
1 |
| 44 |
8621077 | Introducing StuI sites improves vectors for the expression of fusion proteins with factor Xa cleavage sites. | 1996 Apr 17 |
2 |
| 45 |
8880912 | Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. | 1996 Sep |
2 |
| 46 |
7548057 | Intermolecular interactions between protein C inhibitor and coagulation proteases. | 1995 Oct 10 |
1 |
| 47 |
7740449 | Interaction of antistasin-related peptides with factor Xa: identification of a core inhibitory sequence. | 1994 Dec |
1 |
| 48 |
8280781 | Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin. | 1994 Jan 11 |
1 |
| 49 |
1331047 | The role of the COOH-terminal region of antithrombin III. Evidence that the COOH-terminal region of the inhibitor enhances the reactivity of thrombin and factor Xa with the inhibitor. | 1992 Nov 5 |
1 |
| 50 |
1569192 | Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency. | 1992 May |
1 |