Title : Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.

Pub. Date : 2009 Jan 16

PMID : 19010776






2 Functional Relationships(s)
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Protein Name
Organism
1 Mutation of Arg-150 in factor Xa, which interacts with the exosite residues in heparin-activated antithrombin, abrogated the ability of the engineered exosites in alpha1PI to promote factor Xa inhibition. Arginine coagulation factor X Homo sapiens
2 Mutation of Arg-150 in factor Xa, which interacts with the exosite residues in heparin-activated antithrombin, abrogated the ability of the engineered exosites in alpha1PI to promote factor Xa inhibition. Arginine coagulation factor X Homo sapiens