Cholesterol

amyloid beta precursor protein ; Homo sapiens







275 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35209177 Effect of Cholesterol Molecules on Aβ1-42 Wild-Type and Mutants Trimers. 2022 Feb 18 3
2 35620166 Sex-specific lipid dysregulation in the Abca7 knockout mouse brain. 2022 1
3 33057949 Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). 2021 Mar 1
4 33296223 Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization. 2021 Feb 1 3
5 33492944 Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations. 2021 Feb 3 1
6 34110944 The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. 2021 May 1
7 34241229 Effect of cholesterol on the dimerization of C99-A molecular modeling perspective. 2021 Jun 15 2
8 34450034 APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation. 2021 Sep 14 2
9 34524402 Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology. 2021 Oct 1 1
10 34690698 A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders. 2021 2
11 34692675 Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3. 2021 1
12 34718942 Interactions Between Amyloid-β (1-42) and Hydroxyapatite-Cholesterol Spherules Associated with Age-Related Macular Degeneration. 2021 Dec 3
13 34756134 An evidence-based review of neuronal cholesterol role in dementia and statins as a pharmacotherapy in reducing risk of dementia. 2021 Dec 1
14 31841137 Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels. 2020 Feb 1 2
15 31914730 Cholesterol Modulates the Formation of the Aβ Ion Channel in Lipid Bilayers. 2020 Mar 3 9
16 32057047 Surface effects on the degree of twist in amyloid fibril structures. 2020 Mar 12 3
17 32413539 Amyloid-beta (Aβ1-42)-induced paralysis in Caenorhabditis elegans is reduced through NHR-49/PPARalpha. 2020 Jun 21 1
18 32555166 Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1. 2020 Jun 18 3
19 32865299 The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking. 2020 Oct 15 1
20 33135883 Impact of Cholesterol Concentration and Lipid Phase on Structure and Fluctuation of Amyloid Precursor Protein. 2020 Nov 12 5
21 33255194 Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains. 2020 Nov 24 1
22 29325505 The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism. 2019 Jul 4
23 30682043 Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein. 2019 1
24 30686764 Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. 2019 Mar 7 1
25 30849361 Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease. 2019 Mar 7 1
26 31090756 The interactions of an Aβ protofibril with a cholesterol-enriched membrane and involvement of neuroprotective carbazolium-based substances. 2019 Jun 7 4
27 31376793 Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress. 2019 Sep 2
28 31379503 Alzheimer's Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts. 2019 2
29 31474736 Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment. 2019 1
30 31738555 Do Cholesterol and Sphingomyelin Change the Mechanism of Aβ25-35 Peptide Binding to Zwitterionic Bilayer? 2019 Dec 23 1
31 29292465 Interaction of Aβ1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy. 2018 Jan 18 1
32 29409811 Serum Albumin's Protective Inhibition of Amyloid-β Fiber Formation Is Suppressed by Cholesterol, Fatty Acids and Warfarin. 2018 Mar 30 4
33 29858247 Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes. 2018 Jul 20 1
34 30123122 Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword. 2018 4
35 30143535 Membrane cholesterol as regulator of human rhomboid protease RHBDL4. 2018 Oct 5 1
36 27662287 Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. 2017 2
37 27773727 Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives. 2017 Jan 15 1
38 28205163 Hybrid In Silico/In Vitro Approaches for the Identification of Functional Cholesterol-Binding Domains in Membrane Proteins. 2017 2
39 26116815 An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling. 2016 Feb 1
40 26678521 Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer's disease. 2016 2
41 26923021 Inhibition of Cholesterol Biosynthesis Reduces γ-Secretase Activity and Amyloid-β Generation. 2016 3
42 26972288 Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation. 2016 1
43 27013422 Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice. 2016 Jul 1
44 27086970 Phosphatidylcholine protects neurons from toxic effects of amyloid β-protein in culture. 2016 Jul 1 3
45 27352802 Common molecular mechanism of amyloid pore formation by Alzheimer's β-amyloid peptide and α-synuclein. 2016 Jun 29 1
46 27525349 Specific Binding of Cholesterol to C99 Domain of Amyloid Precursor Protein Depends Critically on Charge State of Protein. 2016 Sep 15 4
47 24838626 The role of cholesterol metabolism in Alzheimer's disease. 2015 1
48 25125465 ABCA5 regulates amyloid-β peptide production and is associated with Alzheimer's disease neuropathology. 2015 2
49 25553453 Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. 2015 Jan 1 2
50 25581460 Modulation of Alzheimer's Aβ protofilament-membrane interactions by lipid headgroups. 2015 Mar 18 1