Cocaine

solute carrier family 6 member 3 ; Homo sapiens







327 Article(s)
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51 25850966 Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. 2015 Jun 9
52 25873594 Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. 2015 Jul 2
53 26106364 Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding. 2015 7
54 26146874 Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. 2015 Oct 1
55 26598579 Classic Studies on the Interaction of Cocaine and the Dopamine Transporter. 2015 Dec 31 5
56 23856832 Searching for a neurobiological basis for self-medication theory in ADHD comorbid with substance use disorders: an in vivo study of dopamine transporters using (99m)Tc-TRODAT-1 SPECT. 2014 Feb 1
57 24102293 Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. 2014 Jan 9
58 24269640 Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. 2014 Jul 1
59 24566123 Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. 2014 May 11
60 24576496 Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. 2014 Jul 3
61 24649839 Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. 2014 Mar 2
62 24792462 Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors. 2014 Jun 1 1
63 24947061 Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan). 2014 Aug 2
64 24953830 Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. 2014 Dec 6
65 25247548 Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3). 2014 3
66 25339174 A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter. 2014 Dec 12 1
67 23042662 Application of feedback-controlled bolus plus infusion (FC-B/I) method for quantitative PET imaging of dopamine transporters with [(18)F]β-CFT-FE in conscious monkey brain. 2013 Jan 3
68 23170765 Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporter. 2013 Apr 1
69 23340505 Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. 2013 Jan 22 4
70 23660705 Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. 2013 Oct 2
71 23719505 Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. 2013 Nov 8
72 23731497 Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence. 2013 Dec 1
73 24285320 Tropane-derived (11) C-labelled and (18) F-labelled DAT ligands. 2013 Mar-Apr 1
74 22514303 Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. 2012 Apr 18 1
75 22715379 A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. 2012 1
76 23079638 Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters. 2012 Sep 3
77 20801429 Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. 2011 Feb 1 8
78 20969853 Melittin stimulates fatty acid release through non-phospholipase-mediated mechanisms and interacts with the dopamine transporter and other membrane-spanning proteins. 2011 Jan 15 1
79 21146984 The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. 2011 Jan 1 2
80 21251927 A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants. 2011 May 1
81 21272013 VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse. 2011 Jan 1
82 21298009 The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. 2011 Jan 27 2
83 21402130 Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection. 2011 May 19 3
84 21420984 Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113. 2011 Jul-Aug 5
85 21717292 Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia. 2011 Aug 1
86 21785269 Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation. 2011 Nov-Dec 2
87 21859929 Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. 2011 Nov 3
88 22043293 The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. 2011 1
89 19899168 Molecular dynamics of leucine and dopamine transporter proteins in a model cell membrane lipid bilayer. 2010 Mar 2
90 20085610 Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. 2010 Apr 2
91 20201860 Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. 2010 Feb 2
92 20352074 Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. 2010 Mar 17 3
93 20364374 Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models. 2010 May 1
94 20551317 Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. 2010 Aug 27 2
95 20688912 Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. 2010 Oct 15 4
96 20715493 [Methylphenidate: pharmacology, indication and potential of abuse]. 2010 Aug 1
97 20801583 Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. 2010 Dec 2
98 20830722 The DAT ligand [(18)F]PR17.MZ mirrors the in vivo pharmacokinetic profile of [(11)C]cocaine with significantly improved monoamine transporter selectivity. 2010 Oct 4 1
99 20840845 The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization. 2010 Dec 1 2
100 19038779 Cocaine alters vesicular dopamine sequestration and potassium-stimulated dopamine release: the role of D2 receptor activation. 2009 Mar 1