Title : Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways.

Pub. Date : 2013 Oct

PMID : 23602735






1 Functional Relationships(s)
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1 CONCLUSION: Concomitant suppression of MEK/ERK and PI3K/AKT pathways by AZD6244 and GDC0941 abrogates compensatory mechanisms of tumor survival and causes synergistic cytotoxicity in thyroid cancer cells. 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine mitogen-activated protein kinase kinase 7 Homo sapiens