dapt

hes family bHLH transcription factor 1 ; Homo sapiens







51 Article(s)
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1 32980561 JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. 2021 Feb 1
2 33622250 The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation. 2021 Feb 23 1
3 34295560 DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway. 2021 Jun 5
4 34335900 FOXP3 facilitates the invasion and metastasis of non-small cell lung cancer cells through regulating VEGF, EMT and the Notch1/Hes1 pathway. 2021 Sep 1
5 32173531 Inhibition of NOTCH signaling pathway chemosensitizes HCC CD133+ cells to vincristine and 5-fluorouracil through upregulation of BBC3. 2020 May 14 1
6 32695658 Long-Term Inhibition of Notch in A-375 Melanoma Cells Enhances Tumor Growth Through the Enhancement of AXIN1, CSNK2A3, and CEBPA2 as Intermediate Genes in Wnt and Notch Pathways. 2020 1
7 30867133 Synchronization of Hes1 oscillations coordinates and refines condensation formation and patterning of the avian limb skeleton. 2019 Apr 2
8 31023175 Rosuvastatin improves neurite extension in cortical neurons through the Notch 1/BDNF pathway. 2019 Jul 1
9 31073804 Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres. 2019 Jul 1
10 31359737 Small Molecule Glycomimetics Inhibit Vascular Calcification via c-Met/Notch3/HES1 Signalling. 2019 1
11 28482141 Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. 2018 Feb 1
12 29100034 Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients. 2018 Jan 1
13 29253571 Inhibition of Notch signaling pathway using γ-secretase inhibitor delivered by a low dose of Triton-X100 in cultured oral cancer cells. 2018 Jan 15 1
14 30583672 Molecular Targeting of Notch Signaling Pathway by DAPT in Human Ovarian Cancer: Possible Anti Metastatic Effects 2018 Dec 25 1
15 27684192 Co-inhibition of Notch and NF-κB Signaling Pathway Decreases Proliferation through Downregulating IκB-α and Hes-1 Expression in Human Ovarian Cancer OVCAR-3 Cells. 2017 Jan 1
16 27908834 Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines. 2017 Jan 15 1
17 27939630 Endosulfan inhibits proliferation through the Notch signaling pathway in human umbilical vein endothelial cells. 2017 Feb 2
18 28400072 Notch signaling pathway promotes the development of ovine ovarian follicular granulosa cells. 2017 Jun 1
19 28580186 Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells. 2017 May 1
20 29035086 NOTCH Signaling Is Essential for Maturation, Self-Renewal, and Tri-Differentiation of In Vitro Derived Human Neural Stem Cells. 2017 Dec 1
21 29049420 Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling. 2017 1
22 29123981 Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling. 2017 Nov 1
23 26607252 Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons. 2016 Mar 1 1
24 26662286 TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition. 2016 Jan 1
25 27570480 Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway. 2016 1
26 27677287 Numb/Notch signaling pathway modulation enhances human pancreatic cancer cell radiosensitivity. 2016 Nov 1
27 25637797 Enhanced angiogenesis promoted by human umbilical mesenchymal stem cell transplantation in stroked mouse is Notch1 signaling associated. 2015 Apr 2 1
28 26722328 Gastric tumor-initiating CD44+ cells and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT. 2015 Nov 1
29 24251351 Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis. 2014 Feb 1
30 24535252 Pretreatment with the γ-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling. 2014 Apr 1
31 24555978 Notch pathway activation is associated with pancreatic cancer treatment failure. 2014 Jan-Feb 1
32 24851694 [Notch signaling pathway in 1-methyl-4-phenylpyridinium-induced apoptosis of SH-SY5Y cell]. 2014 Apr 8 1
33 24932308 Gastric cancer cell growth and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT. 2014 Jun 1
34 25063285 DAPT suppresses the proliferation of human glioma cell line SHG-44. 2014 Jul 1
35 25073953 Colocalization of β-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation. 2014 Nov 1
36 23219912 Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition. 2013 Mar 1
37 23372773 Regulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres. 2013 1
38 23489689 Jagged-1-HES-1 signaling inhibits the differentiation of TH17 cells via ROR gammat. 2013 Jan-Mar 2
39 23591351 [Effects of DAPT on proliferation of human dental pulp cells and Notch signaling pathway]. 2013 Apr 18 1
40 23671619 Pterostilbene exerts antitumor activity via the Notch1 signaling pathway in human lung adenocarcinoma cells. 2013 1
41 23989618 Hair cell generation by notch inhibition in the adult mammalian cristae. 2013 Dec 1
42 22391171 [Expression of Notch signal molecules in human lymphoma cells and its significance]. 2012 Feb 1
43 22863581 [Notch pathway gene expression after co-culture of umbilical cord mesenchymal stem cells and hematopoietic stem cells]. 2012 Aug 1
44 22931655 [Effect of DAPT on proliferation and apoptosis of human multiple myeloma cell line RPMI8226]. 2012 Aug 2
45 21466361 Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers. 2011 Apr 1
46 21520992 Gamma-secretase inhibitor, a potential target therapy for MUC2-positive colorectal carcinoma. 2011 1
47 20117093 Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780. 2010 Feb 26 1
48 18320325 The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. 2008 Aug 1
49 18642791 [Effects of gamma-secretase inhibitor N-(3, 5-difluorophenacetyl-L-alanyl)-S-phenylglycine t-butyl ester on proliferation and differentiation of neural stem cells]. 2008 Feb 19 1
50 17472726 Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells. 2007 Apr 1