Lapatinib

estrogen receptor 1 ; Homo sapiens







18 Article(s)
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1 34944900 Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer. 2021 Dec 14 1
2 32942617 HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line. 2020 Sep 15 3
3 32988919 Predictive Role of TP53, PIK3CA and MLL2 in ER+ HER2+ Breast Bancer: Biomarker Analysis of Neo-ALL-IN [NCT 01275859]. 2020 Oct 1
4 31477168 A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib, and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2-positive breast cancer (TEAL study). 2019 Sep 2 1
5 29476008 Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy. 2018 Mar 13 1
6 27942916 Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells. 2017 Jan 3
7 29069787 Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. 2017 Sep 22 1
8 27491481 Phase II trial of neoadjuvant letrozole and lapatinib in Asian postmenopausal women with estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-positive breast cancer [Neo-ALL-IN]: Highlighting the TILs, ER expressional change after neoadjuvant treatment, and FES-PET as potential significant biomarkers. 2016 Oct 3
9 26015514 Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy. 2015 Sep 1 1
10 26557906 Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib. 2015 Nov 6
11 24352641 Managing breast cancers with low estrogen receptor and HER2 by drugging both. 2014 Feb 1 1
12 23233650 An open-label study of lapatinib in women with HER-2-negative early breast cancer: the lapatinib pre-surgical study (LPS study). 2013 Apr 1
13 23706161 OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2. 2013 May 24 2
14 22686613 Overcoming treatment resistance in HER2-positive breast cancer: potential strategies. 2012 Jun 18 2
15 20179226 Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance. 2010 Mar 1 6
16 20179241 Does lapatinib work against HER2-negative breast cancers? 2010 Mar 1 1
17 16682622 A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. 2006 May 16 7
18 15665275 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. 2005 Jan 1 4