Fluorouracil

erb-b2 receptor tyrosine kinase 2 ; Homo sapiens







69 Article(s)
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1 34312098 Nine-Year Median Follow-up of Cardiotoxicity and Efficacy of Trastuzumab Concurrently With Anthracycline-Based and Anthracycline-Free Neoadjuvant Chemotherapy in HER2-Positive Breast Cancer Patients. 2022 Jan 2
2 33720069 Changes in the therapeutic landscape of oesophago-gastric cancers. 2021 Jul 1 1
3 34710829 Affibody-conjugated 5-fluorouracil prodrug system preferentially targets and inhibits HER2-expressing cancer cells. 2021 Dec 10 1
4 31918721 Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer. 2020 Jan 9 1
5 32014926 VDR Agonists Increase Sensitivity of MCF-7 and BT-474 Breast Cancer Cells to 5 FU. 2020 Feb 1
6 32235305 Local and Central Evaluation of HER2 Positivity and Clinical Outcome in Advanced Gastric and Gastroesophageal Cancer-Results from the AGMT GASTRIC-5 Registry. 2020 Mar 29 2
7 32727638 Pyrotinib Sensitizes 5-Fluorouracil-Resistant HER2+ Breast Cancer Cells to 5-Fluorouracil. 2020 Dec 10 2
8 30124494 Phase II clinical trial of second-line weekly paclitaxel plus trastuzumab for patients with HER2-positive metastatic gastric cancer. 2019 Jan 2
9 31019975 Pretreatment with Gemcitabine/5-Fluorouracil Enhances the Cytotoxicity of Trastuzumab to HER2-Negative Human Gallbladder Cancer Cells In Vitro and In Vivo. 2019 5
10 29451302 Comparing cytotoxic backbones for first-line trastuzumab-containing regimens in human epidermal growth factor receptor 2-positive advanced oesophagogastric cancer: A meta-analysis. 2018 Jul 15 4
11 29845287 Antitumor effect of lapatinib and cytotoxic agents by suppression of E2F1 in HER2‑positive breast cancer. 2018 Jul 1
12 30056083 Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. 2018 Oct 1
13 28160563 Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer. 2017 Apr 4 1
14 28494379 Study on molecular structure, spectroscopic properties (FTIR and UV-Vis), NBO, QTAIM, HOMO-LUMO energies and docking studies of 5-fluorouracil, a substance used to treat cancer. 2017 Sep 5 3
15 28850174 Chemotherapy for advanced gastric cancer. 2017 Aug 29 3
16 26810644 Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms. 2016 Jan 25 2
17 27626067 Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer. 2016 Sep 1
18 25744576 Efficacy and safety of trastuzumab in combination with oxaliplatin and fluorouracil-based chemotherapy for patients with HER2-positive metastatic gastric and gastro-oesophageal junction adenocarcinoma patients: a retrospective study. 2015 Apr 2
19 25778705 Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. 2015 1
20 25871911 Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine. 2015 Aug 1
21 25901146 Targeted Delivery of 5-fluorouracil with Monoclonal Antibody Modified Bovine Serum Albumin Nanoparticles. 2015 Spring 3
22 26345461 ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab. 2015 Sep 7 1
23 26623038 Superior antitumor activity of trastuzumab combined with capecitabine plus oxaliplatin in a human epidermal growth factor receptor 2-positive human gastric cancer xenograft model. 2015 Sep 3
24 24472145 Correlation between HER-2/neu(erbB-2) expression level and therapeutic effect of combination treatment with HERCEPTIN and chemotherapeutic agents in gastric cancer cell lines. 2014 Jan 29 1
25 23708506 Lapatinib inhibits the growth of esophageal squamous cell carcinoma and synergistically interacts with 5-fluorouracil in patient-derived xenograft models. 2013 Aug 1
26 22222640 HER2 testing in gastric cancer: a practical approach. 2012 May 1
27 22293713 Lapatinib, a dual inhibitor of EGFR and HER2, has synergistic effects with 5-fluorouracil on esophageal carcinoma. 2012 May 3
28 22534547 Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression. 2012 Nov-Dec 1
29 22614071 Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. 2012 Aug 3
30 23422737 Antitumor activity of HM781-36B, a pan-HER tyrosine kinase inhibitor, in HER2-amplified breast cancer cells. 2012 Mar 2
31 21712253 Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells. 2011 Aug 2
32 21985855 Successful treatment of a patient with HER2-positive metastatic gastric cancer with third-line combination therapy with irinotecan, 5-fluorouracil, leucovorin and trastuzumab (FOLFIRI-T). 2011 1
33 20238327 Chemotherapy for advanced gastric cancer. 2010 Mar 17 1
34 20682991 Combination therapy of 5-fluorouracil with rapamycin for hormone receptor-negative human breast cancer. 2010 Jul 1
35 20811704 The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer. 2010 Oct 1
36 21080742 Trastuzumab: in HER2-positive metastatic gastric cancer. 2010 Dec 3 1
37 21160270 [A case of HER2 overexpressing advanced breast cancer with CTF therapy [cyclophosphamide, pirarubicin (THPADM), fluorouracil] showed long-term effectiveness after paclitaxel shock]. 2010 Dec 1
38 19470942 Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013. 2009 Jul 20 1
39 19885610 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. 2009 Dec 4
40 17885815 Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu. 2008 Jan 2
41 18082672 The immunocytokine scFv23/TNF targeting HER-2/neu induces synergistic cytotoxic effects with 5-fluorouracil in TNF-resistant pancreatic cancer cell lines. 2008 Feb 15 3
42 18390970 Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B. 2008 May 10 3
43 17200359 Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. 2007 Jan 1 1
44 18337622 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. 2007 2
45 16137437 HER2 overexpression as a predictive marker in a randomized trial comparing adjuvant cyclophosphamide/methotrexate/5-fluorouracil with epirubicin in patients with stage I/II breast cancer: long-term results. 2005 Aug 1
46 16243820 Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma. 2005 Oct 15 1
47 16315942 [Combination immunotherapy using autologous tumor-stimulated lymphocytes and trastuzumab (Herceptin) for the patients with recurrent breast cancer]. 2005 Oct 1
48 15640503 Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy. 2004 Dec 2
49 12655533 Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. 2003 Apr 1 2
50 12761490 HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. 2003 May 22 1