Title : 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells.

Pub. Date : 2009 Dec

PMID : 19885610






4 Functional Relationships(s)
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1 The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a small dose-dependent anti-proliferative effect, with an IC50 of 90 microM. Fluorouracil erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 The level of ErbB2 was unchanged by 5-fluorouracil alone but was drastically reduced in cells treated with 5-fluorouracil plus apigenin. Fluorouracil erb-b2 receptor tyrosine kinase 2 Homo sapiens
3 The level of ErbB2 was unchanged by 5-fluorouracil alone but was drastically reduced in cells treated with 5-fluorouracil plus apigenin. Fluorouracil erb-b2 receptor tyrosine kinase 2 Homo sapiens
4 Taken together, our results suggest that 5-fluorouracil acts synergistically with apigenin inhibiting cell growth and inducing apoptosis via the down-regulation of ErbB2 expression and Akt signaling. Fluorouracil erb-b2 receptor tyrosine kinase 2 Homo sapiens