Triglycerides

diacylglycerol O-acyltransferase 1 ; Homo sapiens







116 Article(s)
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1 34757839 Lipid Droplets Are Beneficial for Rabies Virus Replication by Facilitating Viral Budding. 2022 Jan 26 2
2 33465519 Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes. 2021 May 2
3 34095320 DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis. 2021 2
4 34116261 DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells. 2021 Sep 3
5 34160713 Discovery of novel DGAT1 inhibitors by combination of machine learning methods, pharmacophore model and 3D-QSAR model. 2021 Aug 1
6 31652233 Physical Activity and Genome-wide DNA Methylation: The REgistre GIroní del COR Study. 2020 Mar 1
7 31937853 Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. 2020 Jan 14 4
8 32138658 Genome-wide identification of Diacylglycerol Acyltransferases (DGAT) family genes influencing Milk production in Buffalo. 2020 Mar 6 2
9 32433611 Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. 2020 May 3
10 32438640 Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. 2020 May 19 2
11 32559414 Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress. 2020 Aug 4 2
12 32878484 Patent landscape for discovery of promising acyltransferase DGAT and MGAT inhibitors. 2020 Nov 1
13 33235909 DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy. 2020 Sep 8 2
14 30647103 Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. 2019 Apr 1
15 30658160 Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes. 2019 Mar 1
16 30718413 DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. 2019 Feb 19 2
17 30790345 A population analysis of the DGAT1 inhibitor GSK3008356 and its effect on endogenous and meal-induced triglyceride turnover in healthy subjects. 2019 Oct 4
18 30899516 Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol. 2019 Apr 2
19 30950565 First-in-Human Pharmacokinetics and Safety Study of GSK3008356, a Selective DGAT1 Inhibitor, in Healthy Volunteers. 2019 Nov 4
20 31049804 D-ribose increases triglyceride via upregulation of DGAT in the liver. 2019 Jun 1
21 31315900 DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells. 2019 Oct 2
22 31331203 In silico design of diacylglycerol acyltransferase-1 (DGAT1) inhibitors based on SMILES descriptors using Monte-Carlo method. 2019 Aug 2
23 31413796 Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor. 2019 Aug 8 2
24 31456800 A Novel Role for Triglyceride Metabolism in Foxp3 Expression. 2019 1
25 31657789 A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids. 2019 Oct 13 2
26 29523747 Substrate preferences of long-chain acyl-CoA synthetase and diacylglycerol acyltransferase contribute to enrichment of flax seed oil with α-linolenic acid. 2018 Apr 30 1
27 29563512 The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function. 2018 Mar 21 2
28 29604290 Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency. 2018 Jul 2
29 30018616 Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection. 2018 1
30 30077544 Role of DGAT enzymes in triacylglycerol metabolism. 2018 Oct 1 1
31 27788579 A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial. 2017 Feb 10 1
32 27855567 Pradigastat disposition in humans: in vivo and in vitro investigations. 2017 Dec 4
33 28328322 Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors. 2017 Apr 6
34 28373485 Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. 2017 Jun 4
35 28751309 Fat-containing cells are eliminated during Dictyostelium development. 2017 Sep 15 1
36 28768178 Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. 2017 Aug 1 1
37 28802563 Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues. 2017 Nov 1
38 28806138 Lipid droplets and lipotoxicity during autophagy. 2017 2
39 28877685 Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5. 2017 Sep 6 1
40 28994204 Directed evolution of DGAT1 to increase triacylglycerol content. 2017 Oct 1
41 26493024 Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells. 2016 Jan 4
42 27531967 Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome. 2016 Oct 15 1
43 27706370 Diversity and evolution of plant diacylglycerol acyltransferase (DGATs) unveiled by phylogenetic, gene structure and expression analyses. 2016 Oct-Dec 3
44 25792450 Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes. 2015 May 5
45 25889044 Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome. 2015 Feb 18 5
46 25997070 Effects of phenotypic and genotypic factors on the lipid responses to niacin in Chinese patients with dyslipidemia. 2015 May 3
47 26228353 Identification of genes coding for putative wax ester synthase/diacylglycerol acyltransferase enzymes in terrestrial and marine environments. 2015 Dec 1
48 26246845 Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial. 2015 5
49 24529140 Adipose tissue diacylglycerol acyltransferase activity and blood lipoprotein triglyceride enrichment in women with abdominal obesity. 2014 Mar 1
50 24562909 Dictyostelium discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis. 2014 Apr 1