phosphatase and tensin homolog ; Homo sapiens






2610 Article(s)
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1 675837 Small-scale trials of six drugs against Onchocerca volvulus. Tropenmed Parasitol 1978 Jun 2
2 3808054 Platelets mediate the action of diethylcarbamazine on microfilariae. Nature 1987 Feb 5-11 2
3 4017101 Phosphate buffer and salt medium concentrations affect the inactivation of T4 phage by platinum(II) complexes. Chem Biol Interact 1985 Jun 5
4 7630209 Bleeding and thromboembolism during anticoagulant therapy: a population-based study in Rochester, Minnesota. Mayo Clin Proc 1995 Aug 1
5 9256433 P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A 1997 Aug 19 6
6 9259288 Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum Mol Genet 1997 Aug 2
7 9399897 Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis. Am J Hum Genet 1997 Dec 1
8 9467947 Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. Oncogene 1998 Jan 8 4
9 9510470 Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. Jpn J Cancer Res 1998 Jan 2
10 9560261 Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci U S A 1998 Apr 28 2
11 9593664 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998 May 29 9
12 9616126 Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998 Jun 5 1
13 9622068 Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res 1998 Jun 1 2
14 9796706 Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene 1998 Oct 1 2
15 9797362 Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. Gastroenterology 1998 Nov 1
16 9811831 The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A 1998 Nov 10 4
17 9823298 The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res 1998 Nov 15 1
18 9860981 PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci U S A 1998 Dec 22 1
19 9865719 The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res 1998 Dec 15 3
20 9885576 The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 1998 Dec 5
21 9927060 Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res 1999 Jan 15 2
22 9931326 PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet 1999 Feb 5
23 10022807 Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase. Oncogene 1999 Feb 11 1
24 10051603 Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1999 Mar 2 5
25 10188904 Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas. Br J Cancer 1999 Mar 2
26 10200246 New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999 Apr 13 1
27 10203785 PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999 Apr 2
28 10209098 Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr Biol 1999 Mar 25 3
29 10209156 Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999 Apr 2
30 10377431 The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci U S A 1999 Jun 22 1
31 10400703 PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 1999 Jul 16 3
32 10400993 PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet 1999 Aug 1
33 10415336 PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation. Gene 1999 Jul 22 2
34 10417424 [PTEN: a tumor suppressor with original properties]. Bull Cancer 1999 Jun 5
35 10469123 PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur J Biochem 1999 Aug 4
36 10485448 Alterations of the PPP1R3 gene in human cancer. Cancer Res 1999 Sep 1 1
37 10485474 Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999 Sep 1 1
38 10503872 Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability. Cancer Lett 1999 Sep 20 2
39 10547389 PTEN gene and integrin signaling in cancer. J Natl Cancer Inst 1999 Nov 3 1
40 10554022 The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. Cancer Res 1999 Nov 1 3
41 10555148 Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999 Oct 29 3
42 10564676 Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999 Nov 17 8
43 10582703 PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res 1999 Nov 15 1
44 10597304 The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 1999 Nov 25 1
45 10617573 Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev 1999 Dec 15 2
46 10644997 The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity. Oncogene 2000 Jan 13 1
47 10646847 Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res 2000 Jan 1 4
48 10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol 2000 Feb 1
49 10657643 The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. J Immunol 2000 Feb 15 1
50 10698513 Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene 2000 Feb 3 6