| Protein Name | protein tyrosine phosphatase, non-receptor type 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24697 |
| Gene Symbol | Ptpn1 |
| UniProt | P20417 (PTN1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
173
Total Number of Articles : 154 |
Description |
protein tyrosine phosphatase, non-receptor type 1 |
| Gene Summary |
Enables insulin receptor binding activity; protein phosphatase 2A binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including cellular response to peptide hormone stimulus; positive regulation of apoptotic process; and regulation of protein metabolic process. Located in mitochondrial crista and mitochondrial matrix. Is active in glutamatergic synapse and postsynapse. Biomarker of hyperinsulinism and hypertension. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Jul 2025] |
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