Protein Name protein tyrosine phosphatase, non-receptor type 1
Organism Rattus norvegicus
Gene ID 24697
Gene Symbol

Ptpn1

UniProt P20417 (PTN1_RAT)
Relationships Total Number of functionally related compound(s) : 173
Total Number of Articles : 154
Description

protein tyrosine phosphatase, non-receptor type 1

Gene Summary

Enables insulin receptor binding activity; protein phosphatase 2A binding activity; and protein tyrosine phosphatase activity. Involved in protein dephosphorylation and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle; cytosol; and mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tyrosine-protein phosphatase non-receptor type 1
  • PTP-1B
  • protein-tyrosine phosphatase 1B
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Properties