| Protein Name | interleukin 6 signal transducer |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16195 |
| Gene Symbol | Il6st |
| UniProt | Q00560 (IL6RB_MOUSE), Q6PDI9 (Q6PDI9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
95
Total Number of Articles : 110 |
Description |
interleukin 6 signal transducer |
| Gene Summary |
Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and immunodeficiency 94. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |