Protein Name serine hydroxymethyltransferase 2
Organism Homo sapiens
Gene ID 6472
Gene Symbol

SHMT2

UniProt P34897 (GLYM_HUMAN), B4DLV4 (B4DLV4_HUMAN), V9HW06 (V9HW06_HUMAN), Q5HYG8 (Q5HYG8_HUMAN), B4DJQ3 (B4DJQ3_HUMAN), A0A024RB99 (A0A024RB99_HUMAN), Q5BJF5 (Q5BJF5_HUMAN)
Relationships Total Number of functionally related compound(s) : 91
Total Number of Articles : 93
Description

serine hydroxymethyltransferase 2

Gene Summary

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

synonyms
  • serine hydroxymethyltransferase, mitochondrial
  • GLY A+
  • epididymis secretory sperm binding protein Li 51e
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Properties